There are interactions and feedbacks between air pollution as a driver of environmental change, climate change, and overall ecosystem health. Air pollution is a major environmental problem, particularly in developing countries where regulations may be lax. This paper explores the nexus between air pollution, climate change and overall ecosystem health in the Niger Delta region of Nigeria. It brings novelty by exploring these issues with an environmental justice lens. This is particularly pertinent due to the ecological sensitiveness of the region and the high dependence of the indigenes on the land and water. The region’s ecosystem is becoming more and more threatened as pollution increases and the climate changes further. Nigeria’s position as the largest oil producer in Africa and the sixth largest in the world is due to the oil and gas reserves of its Niger Delta region. The irony becomes that while the region is the mainstay of the Nigerian economy or is a source of national ‘good’, they have received in return only environmental ‘bads’. The many levels of deprivation experienced by the indigenes of the Niger Delta is a classic case of environmental injustice where the region disproportionately bears a much higher burden of air, land, and water pollution in comparison to other parts of the country. Gas flaring, fossil fuel burning, artisanal refining of crude, and transportation are found to be the main sources of air pollution in the locality. Mitigating air pollution and the attendant impacts requires urgent action and concerted effort at the individual, local and national levels. This paper provides recommendations in this regard.