Cadmium (Cd) contamination in edible agricultural products, especially in crops, has raised worldwide concerns regarding food safety consumption. This review summarizes the current knowledge of the applicable methods and perspectives for reducing Cd contamination of agricultural products. Agricultural approaches of soil amendments, irrigation management, microbial agent, and cropping patterns were systematically concluded to illustrate the developments and achievements in crop contamination management. The use of traditional soil amendments as well as novel nano-materials has contributed to producing safe crops in agricultural soil contaminated with Cd. This review provides an inspiring and promising tool for maintaining food safety by reducing Cd accumulation in edible agricultural products.

Soil Cadmium (Cd) contamination is a worldwide problem with negative impacts on human health. Cultivating the Cd-Pollution Safety Cultivar (Cd-PSC) with lower Cd accumulation in edible parts of plants is an environmentally friendly approach to ensure food security with wide application prospects. Specialized mechanisms have been addressed for Cd accumulation in crops. This review provides an extensive generality of molecular regulation mechanisms involved in Cd absorption, transport, detoxification, and tolerance in plants, highlighting key aspects of rhizosphere, apoplast barrier, Cd uptake, transfer, and cellular repair strategies under Cd stress. Additionally, we summarize the possible approaches for lowering the Cd accumulation crops, including molecular-assistant breeding, applying chemical materials, and microbial strategy to decrease Cd content in edible parts and improve Cd tolerance of crops under Cd stress. This review would provide valuable insights for cultivating low Cd accumulated crop cultivars, ultimately contributing to food safety.