The emergence of flexible wearable electronics as a new platform for accurate, unobtrusive, user-friendly, and longitudinal sensing has opened new horizons for personalized assistive tools for moni... 概要正確で目立たずユーザーフレンドリーで縦方向の検知力のある新たなプラットフォームとして、フレキシブルでウェアラブルな電子装置が新たに登場したことにより、ヒトの歩行運動ならびに生理学的信号のモニタリングを補助するカスタマイズ可能なツールの分野は新たな局面に入った。本文では、胴体と四肢の大きな動きまたは体位検出時などの、中程度から大規模な範囲の加圧や動作を目立たないように検知するために必要な方... 초록플렉서블 웨어러블 전자제품이 정확하고, 눈에 거슬리지 않고, 사용자 친화적이고, 장기적인 센서의 새로운 플랫폼으로 등장하여 인간의 움직임과 생리 신호를 모니터링하는 개인화 보조 도구의 새로운 지평을 열었다. 본 연구에서는 신체 및 팔다리의 커다란 움직임이나 자세 감지 등 중간/넓은 범위의 압력과 움직임을 눈에 비간섭적으로 감지하는 방법과 소재의 최... 摘要作为精确、非侵入、用户友好和纵向感知的新平台,柔性可穿戴电子产品的出现为人体运动和生理信号监测的个性化辅助工具开辟了新的领域。在本文中,我们对涉及非侵入式感知的方法和材料的最新进展进行了概述,其涉及到对中到大范围的压力和运动(如在大范围的身体和肢体活动或姿态检测中遇到的的压力和运动)进行非侵入式感知,。我们将讨论三种常用的人体步态研究方法:惯性、光学和角度传感器。随后,我们将调查集成到这...
5 September 2017 in ACS Applied Materials & Interfaces
Traditional textile materials can be transformed into functional electronic components upon being dyed or coated with films of intrinsically conducting polymers, such as poly(aniline), poly(pyrrole) and poly(3,4-ethylenedioxythiophene).
Nanobodies are single variable domain antibodies isolated from camelids and are rapidly distinguishing themselves as ideal recognition elements in biosensors due to their comparative stability, ease of production and isolation, and high binding affinities. However, transducing analyte binding by nanobodies in real time is challenging, as most nanobodies do not directly produce an optical or electrical signal upon target recognition. Here, we report a general strategy to fabricate sensitive and selective electrochemical sensors incorporating nanobodies for detecting target analytes in heterogeneous media, such as cell lysate. Graphite felt can be covalently functionalized with recombinant HaloTag-modified nanobodies. Subsequent encapsulation with a thin layer of a hydrogel using a vapor deposition process affords encapsulated electrodes that directly display a decrease in current upon antigen binding, without added redox mediators. Differential pulse voltammetry affords clear and consistent decreases in electrode current across multiple electrode samples for specific antigen concentrations. The change in observed current vs increasing antigen concentration follows Langmuir binding characteristics, as expected. Importantly, selective and repeatable target binding in unpurified cell lysate is only demonstrated by the encapsulated electrode, with an antigen detection limit of ca. 30 pmol, whereas bare electrodes lacking encapsulation produce numerous false positive signals in control experiments.
22 January 2019 in Advanced Materials Technologies