In utero exposure to smoking is known to adversely affect brain regions involved in behavioral state organization and could therefore interact with the neurophysiological development of neonates. The present study investigated the effects of prenatal smoking exposure on sleep patterns in the preterm neonate. Overnight sleep patterns were polysomnographically assessed at thermoneutrality. Sleep continuity and structure were scored for the respective frequencies, durations and percentages of active, quiet, and indeterminate sleep and wakefulness after sleep onset. The number and duration of body movements were also analyzed. The neonatal intensive care unit at Amiens University Medical Center (France). Healthy preterm neonates (postconceptional age: 33.9 ± 6.0 weeks) were enrolled according to whether their mothers had not smoked at all during pregnancy (control group, n = 19), smoked less during pregnancy (low-smoking group, S_low, n = 10), or smoked more (heavy-smoking group, S_heavy, n = 10) than 10 cigarettes per day throughout pregnancy. Neonates born to heavy-smoking mothers had a significantly lower mean birth weight than controls (–21%) and displayed disrupted sleep structure and continuity: they slept less overall (with a higher proportion of active sleep and a lower proportion of quiet sleep) and had more wakefulness after sleep onset. Compared with controls, neonates from both smoking groups displayed more body movements and, as a result, more disturbed sleep. High prenatal smoking exposure modifies sleep patterns in preterm neonates by disrupting sleep organization and increasing nocturnal body movements. These findings raise the question of the repercussions of these sleep disturbances (at what is a critical stage in brain development) on the child's physiological and neurobehavioral outcomes.

It has been suggested that disturbed activity of the autonomic nervous system is one of the factors involved in gastroesophageal reflux (GER) in adults. We sought to establish whether transient ANS dysfunction (as assessed by heart rate variability) is associated with the occurrence of GER events in neonates during sleep and wakefulness. Nineteen neonates with suspected GER underwent simultaneous, synchronized 12-hour polysomnography and esophageal multichannel impedance-pH monitoring. We compared changes in HRV parameters during three types of periods (control and prior to and during reflux) with respect to the vigilance state. The vigilance state influenced the distribution of GER events (P<0.001), with 53.4% observed during wakefulness, 37.6% observed during active sleep and only 9% observed during quiet sleep. A significant increase in the sympathovagal ratio (+32%, P=0.013) was observed in the period immediately prior to reflux (due to a 15% reduction in parasympathetic activity (P=0.017)), relative to the control period. This phenomenon was observed during both wakefulness and active sleep. Our results showed that GER events were preceded by a vigilance-state-independent decrease in parasympathetic tone. This suggests that a pre-reflux change in ANS activity is one of the factors contributing to the mechanism of reflux in neonates.

Low back pain (LBP) that radiates to the leg is not always related to a lesion or a disease of the nervous system (neuropathic pain): it might be nociceptive (referred) pain. Unfortunately, patients with low-back related leg pain are often given a variety of diagnoses (e.g. ‘sciatica’; ‘radicular pain’; pseudoradicular pain”). This terminology causes confusion and challenges clinical reasoning. It is essential for clinicians to understand and recognize predominant pain mechanisms. This paper describes pain mechanisms related to low back-related leg pain and helps differentiate these mechanisms in practice using clinical based scenarios. We illustrate this by using two clinical scenarios including patients with the same symptoms in terms of pain localization (i.e. low-back related leg pain) but with different underlying pain mechanisms (i.e. nociceptive versus neuropathic pain).

Background: Occupational stress and shift work (including night shift work) are associated with physical and psychological health consequences in healthcare providers in general and those working in psychiatric establishments in particular. The aim of this study was to assess the impact of occupational risk factors and unscheduled night-time naps on self-reported health disorders among nurses working in a French psychiatric hospital. Methods: We performed a 12-month observational field study of experienced nurses working at Philippe Pinel Psychiatric Hospital (Amiens, France) between September 2018 and September 2019. A comparative descriptive study of two groups of nurses who filled out a questionnaire on health and occupational stress was performed: nurses working permanently on the night shift (the night shift group, who took unscheduled naps), and nurses rotating weekly between morning and afternoon shifts (the day shift group). Results: The night and day shift groups comprised 53 and 30 nurses, respectively. There were no intergroup differences in health disorders, sleep quality, occupational stress, and risk factor perception. Correlation analyses showed that in the day shift group, a low level of support from supervisors was associated with elevated levels of distress, anxiety, and gastrointestinal disorders. In the night shift group, a greater overall work load was associated with elevated levels of anxiety and distress. These findings indicated that the nurses on the night shift had adapted well to their working conditions. Conclusions: An organizational strategy including an unscheduled night-time nap might improve health among night shift nurses.