Background: Aging is a natural biological process influenced by multiple factors and is a significant contributor to various chronic diseases. Slowing down the aging process and extending health span have been pursuits of the scientific field. Methods: Examination of the effects of dietary polyphenols on hallmarks of aging such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Results: Polyphenols, abundant in nature, exhibit numerous biological activities, including antioxidant effects, free radical scavenging, neuroprotection, and anti-aging properties. These compounds are generally safe and effective in potentially slowing aging and preventing age-related disorders. Conclusions: The review encourages the development of novel therapeutic strategies using dietary polyphenols to create holistic anti-aging therapies and nutritional supplements.

The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut’s immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article.

Nutritional biomarkers can be used as important indicators of nutritional status and play crucial roles in the prevention as well as prognosis optimization of various metabolism-related diseases. Measuring dietary with the deployment of biomarker assessments provides quantitative nutritional information that can better predict the health outcomes. With the increased availability of nutritional biomarkers and the development of assessment tools, the specificity and sensitivity of nutritional biomarkers have been greatly improved. This enables efficient disease surveillance in nutrition research. A wide range of biomarkers have been used in different types of studies, including clinical trials, observational studies, and qualitative studies, to reflect the relationship between diet and health. Through a comprehensive literature search, we reviewed the well-established nutritional biomarkers of vitamins, minerals, and phytonutrients, and their association with epidemiological studies, to better understand the role of nutrition in health and disease.

Objectives: To evaluate the effects of digital health intervention (DHI) or/and personalized healthy breakfast guidance (PHBG) on the breakfast behavior and body composition of young adults in Tianjin, and to explore the underlying behavioral mechanisms using the Health Action Process Approach (HAPA) framework. Methods: In this single-blind, stratified RCT, 160 participants (n = 40/group) were randomly assigned to a control group, DHI group, PHBG group, or DHI + PHBG group. Breakfast behavior (primary outcome), HAPA constructs, and body composition were assessed at baseline and after 1 month. Group differences were analyzed using the Kruskal–Wallis test, chi-square test, and linear mixed-effects models. Mediation analysis assessed indirect effects via HAPA variables. Results: After a 1-month intervention, adherence to healthy breakfast guidelines was highest in the DHI + PHBG group (80%), followed by the PHBG (72.5%) and DHI (50%) groups, compared to 7.5% in the control group (χ² = 51.127, p < 0.001, DHI + PHBG group > DHI group: χ² = 7.912, p < 0.05). All interventions advanced participants along HAPA stages (H = 34.678, p < 0.001) and improved self-efficacy and planning. PHBG and DHI + PHBG further enhanced outcome expectations, intention, and, for the DHI + PHBG group, self-monitoring. Self-efficacy mediated 17.636% of the PHBG effect and 13.305% of the DHI + PHBG effect, and self-monitoring mediated 7.401% of the DHI + PHBG effect. Waist-to-hip ratios decreased modestly in all intervention groups (β = −0.015 to −0.013, p < 0.05), but no significant changes were observed in other body composition indices. Conclusions: DHI, PHBG, and especially their combination, improved breakfast habits in young adults, with self-efficacy as a key mediator. However, the effects of these interventions on body composition were limited due to the short duration of the trial.