Introduction and aim. Anabolic-androgenic steroids (AAS) are used for the rapid enhancement of muscular mass and optimization of athletic performance. Their administration is frequently linked with a plethora of adverse health implications. The primary objective of this study is to provide a comprehensive analysis of multifaceted impacts of anabolic-androgenic steroids on the human body. Material and methods. A review of literature was performed by searching PubMed and GoogleScholar databases using the following key words: anabolic-androgenic steroids, muscular hypertrophy, female masculinization. Analysis of the literature. Anabolic-androgenic steroids are synthetically manufactured derivatives of testosterone. Given the widespread distribution of the androgen receptor, the effects of these steroids are broad, influencing almost all bodily functions. Their impacts include, promoting muscular hypertrophy including that of the cardiac muscle, premature epiphyseal closure, liver diseases, masculinization in females, feminization in males, and degradation in sperm quality. Conclusion. AAS consumption is a significant public health problem. While they may appeal to users by enhancing their physical attractiveness they carry multiple health consequences. Patients should be educated about the adverse effects of taking AAS so they can make informed decision about starting or stopping their use.

Introduction and objective: Obesity is an environmental chronic disease and its significance in public health is constantly increasing. Adipose tissue exhibits hormonal activity and the substances it produces, called adipokines play a role in the regulation of energy supply and...

Musculoskeletal disorders have a significant negative impact on the quality of life of the population. These conditions, as well as other work-related disorders, generate costs associated with treatment and work absence, which makes it a growing problem in industrialized countries. Available data from studies on individual populations of workers indicate a higher incidence of certain symptoms in these groups. Due to the lack of studies on the general population, we aimed to perform the preliminary study evaluating the occurrence of pain and work-related conditions depending on the type of occupational work among Polish employees to identify further possible areas for research. Data was collected using an electronic self-administered questionnaire, which was distributed in groups bringing together various professionals. The data obtained from 379 participants have been analyzed and divided according to performed work into sedentary, forced posture, standing, physical and requiring physical activity. Our study reveals a correlation between the frequency of work-related disorders and type of work performed in the Polish population. A significant correlation between the type of occupational work and prevalence of ankle, knee and shoulder pain, as well as heavy legs or upper limb paresthesia was found. According to our findings, female employees may be more vulnerable to lower limb symptoms. A place of residence also seems to affect the prevalence of upper back pain and heavy legs. The analysis also showed a correlation between the occurrence of hip, knee and ankle pain and the level of education of the participants. Surprisingly, lower extremity paresthesia was significantly more common among participants undertaking additional physical activity, compared to non-physically active respondents.

Over the last decades, along with progress and development of using ionizing radiation, including the fields of power engineering or nuclear weapons, it was possible to observe and describe negative effects of the radiation on human body. The phenomenon referred to as acute radiation syndrome describes the effects of radiation on living cells, depending on exposure time and absorbed dose, which affects the functioning of entire organism after the exposure. The following work describes how ionizing radiation causes changes at the cellular and tissue level, both directly and indirectly, taking into account the variables affecting final effects of exposure. Consecutive phases of acute radiation syndrome were distinguished, and the focus was also on individual groups of disorders resulting from exposure, which may overlap and coexist, i.e. hematopoietic syndrome, gastrointestinal syndrome and neurovascular syndrome, as well as developing multi-organ failure in some of the cases, leading to the patient's death. Exposure to ionizing radiation can result in diversified, variably intensified and spread over time symptoms from many organ systems. Depending on the characteristics of the exposure, its effects will differ, and thus the prognosis for the patient.

Introduction and purpose: The growing number of obese people is one of the greatest problems of modern medicine. It is estimated that every 10th person is obese. Recent studies also suggest that the gut microbiome may contribute to the pathogenesis of obesity. Description of the state of knowledge: Microbiota is named a super organ that has the ability to evolve in response to changing conditions within the host organism. It is named so because it is made up of over 100,000 billion cells that belong to different groups of organisms. Microbiota consists of bacteria, fungi, protists, viruses and archaea. This taxonomically diverse collective plays a vital role in maintaining the homeostasis of the human body. A well-balanced intestinal flora protects the digestive tract from colonization by pathogenic microorganisms, it is also important in maintaining the integrity of the intestinal walls, is involved in the synthesis of certain vitamins and plays a role in nourishing mucosa cells. Moreover, it is known that the microflora can influence body weight, insulin sensitivity, and metabolism of certain sugars and lipids. Disturbances in the composition of the microbiome (dysbiosis) lead to an increased absorption of short-chain fatty acids, which leads to an increase in endogenous YY peptide synthesis. This protein slows down the intestinal transit and indirectly leads to increased absorption of nutrients. This predisposes to the development of obesity. The use of prebiotics, probiotics and some antibiotics reduces intestinal dysbiosis. For obese patients, it is associated with reduction of insulin resistance and decrease in blood glucose level. Conclusions: In the light of the available studies, it can be concluded that intestinal dysbiosis may play a role in the pathogenesis of obesity. Unfortunately, the practical application of this knowledge is not yet well documented. Therefore this topic requires further experiments and analysis.

Introduction and aim. In recent years growing awareness of the society regarding healthy lifestyle leads to increased interest in regular physical activity and usage of dietary supplements. Creatine supplementation is often used among athletes to improve muscle mass, performance and recovery. The aim of this paper is to present the effects of creatine supplementation as well as its function in the body, forms and ways of intake, and potential benefits of its use. Material and methods. A review of the available literature was performed by searching the PubMed and GoogleScholar databases using the following keywords: creatine, creatine supplementation, sports nutrition, brain function Analysis of literature. Creatine is one of the most popular supplements recommended for athletes. It catalyzes transfer of phosphate groups into high energy compounds contributing in energy transportation and cellular energy buffering for cells and tissues with high energy demands. Its supplementation improves exercise performance, increases muscle mass and enhances recovery after training. In addition, there are indications that creatine shows promise in reducing symptoms associated with concussion, mild traumatic brain injury, and depression. Conclusion. Creatine supplementation is used in sport mainly to improve exercise performance and muscle gain, however, it also plays an important role in brain function. In future it may be used in reducing symptoms associated with concussion, mild traumatic brain injury and depression.