Studies on the chemical constituents of the aerial part of Centella asiatica have led to the isolation of three new compounds, named centellin (1), asiaticin (2), and centellicin (3). Their structures have been elucidated through spectral studies including 2D NMR experiments (HMQC, HMBC, 1H–1H COSY, NOESY and J resolved).
1 January 2007 in Chemical and Pharmaceutical Bulletin
The present article describes the analysis of an n-hexane soluble fraction of fresh flowers of Azadirachta indica A. Juss (Neem), possessing larvicidal activity against Anopheles stephensi Liston, a vector of malarial parasite. Forty-one compounds were identified in non-polar to less-polar fraction as well as in essential oil. These identifications were basically made through GC-EIMS. Thus 5 sesquiterpenes, 3 aromatics, 17 fatty acids, 5 fatty acid esters, three steroids and 8 hydrocarbons were identified. The compounds 1–5, 10, 14–17, 21a and 36–38 were reported previously from different parts of the tree including flowers. The rest of the compounds are reported for the first time from flowers.
Studies on the chemical constituents of the aerial parts of Ocimum basilicum have led to the isolation of a new ferulate, 4′-carbomethoxy-2′-hydroxy phenyl ferulate (1) and a new cinnamate, (E)-3′-hydroxy-4′-(1″-hydroxyethyl)-phenyl-4-methoxycinnamate (2). Their structures have been elucidated through spectral studies including 2D-NMR experiments (HMQC, HMBC, COSY-45°, NOESY and 2D-J resolved).