Liquid crystal monomers (LCMs) are widely used chemicals and ubiquitous emerging organic pollutants in the environment, some of which have persistent, bio-accumulative, and toxic potentials. Elevated levels of LCMs have been found in the e-waste dismantling associated areas. However, information on their internal exposure bio-monitoring is scarce. For the first time, occurrences of LCMs were observed in the serum samples of occupational workers (n = 85) from an e-waste dismantling area in South China. Twenty-nine LCMs were detected in serum samples of the workers, with a median value of 35.2 ng/mL (range: 7.78-276 ng/mL). Eight noticed LCMs were found to have relatively high detection frequencies ranging from 52.9% to 96.5%. The correlation analysis of individual LCMs indicated potential common applications and similar sources to the LCMs in occupational workers. Fluorinated LCMs were identified as the predominant monomers in the workers. Additionally, the estimated daily intake of the LCMs in the occupational workers was significantly higher than those in residents from the reference areas (p < 0.05, Mann-Whitney U Test, median values: 1.46 ng/kg bw/day versus 0.40 ng/kg bw/day), indicating a substantially higher exposure level to e-waste dismantling workers.

Liquid crystal monomers (LCMs) are a class of emerging, persistent, bioaccumulative, and toxic organic pollutants. They are detected in various environmental matrixes that are associated with electronic waste (e-waste) dismantling. However, their occurrence and distribution in indoor and outdoor dust on a national scale remain unknown. In this study, a dedicated target analysis quantified a broad range of 60 LCMs in dust samples collected across China. The LCMs were frequently detected in indoor (n = 48) and outdoor dust (n = 97; 37 sampled concomitantly with indoors dust) from dwellings, and indoor dust from cybercafés (n = 34) and phone repair stores (n = 22), with median concentrations of 41.6, 94.7, 106, and 171 ng/g, respectively. No significant spatial difference was observed for the concentrations of the total LCMs among distinct geographical regions (p > 0.05). The median daily intake values of the total LCMs via dust ingestion, dermal contact, and inhalation were estimated at 1.50 × 10^-2, 2.90 × 10^-2, and 8.57 × 10^-6 ng/kg BW/day for adults and 1.47 × 10^-1, 1.22 × 10^-1, and 2.18 × 10^-5 ng/kg BW/day for children, respectively. These estimates suggested higher exposure risks for children and indicated that dust ingestion and dermal contact significantly contribute to the human intake of LCMs. The microenvironmental pollution levels of LCMs together with the potential exposure risks associated with some of these chemicals are of concern for human health.

Aromatic amine antioxidants (AAs), extensively used in rubber products, and their ozone-photolyzed product p-phenylenediamine quinones (PPD-Qs) were found to be pervasive in various environments and with potential ecological and health risks. The relationship between external and internal exposure to these contaminants and their exposure risks to the general population remain poorly explored. Herein, dust-handwipe-urine samples (n = 97 pairs) from families in Tianjin, China was collected for analyzing 20 AAs and 6 PPD-Qs (including self-synthesized emerging PPD-Qs). The median concentration of ∑₂₀AAs (1310 ng/g, 354 ng/m², and 18.5 ng/mL, respectively) and ∑₆PPD-Qs (1645 ng/g, 3913 ng/m² and 3.76 ng/mL, respectively) in dust, handwipe, and urine samples indicated a non-negligible contamination of AAs and PPD-Qs in indoor environment. Notably, emerging DPPD-Q and DNPD-Q (oxidation products of DPPD and DNPD, respectively) were prominent, accounting for >90% of PPD-Qs. The correlation analysis and estimated daily intake (EDI) assessments indicated that neither dust ingestion nor dermal exposure may be the primary source of internal exposure to AAs and PPD-Qs in the general population, and other exposure pathways (e.g., diet and inhalation) may exist. In vitro HepG2 cell experiments demonstrated that both PPD-Qs and PPDs may have potential exposure risk of hepatotoxicity.

Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they can cross the placenta and affect placental development remains unexplored. Here, we develop an evaluation system that integrates human biomonitoring, uterine perfusion in pregnant rats, and placental cells. We find fourteen out of the fifty-six LCMs that are detected in maternal and cord serum samples from ninety-three healthy pregnant women, at median levels of 13.9 and 18.1 ng/mL, respectively. Subsequent explorations of in utero exposure in rats indicate that aromatic amino acid transporter 1 (SLC16A10) mediates transplacental transportation of the LCMs. Placental cells exposed to LCMs exhibit delayed placental development and reduced progesterone release. These findings show that SLC16A10-mediated transplacental transportation of LCMs inhibits placental development and progesterone release, highlighting the importance of gestational exposure to emerging contaminants.