Siyao Gao

Dr. Siyao Gao


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 November 2024 in BMC Public Health
Verified
Journal Article
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YLYuhang Liu
Yuhang Liu
WLWeidong Li
Weidong Li
JTJialing Tang
Jialing Tang
SGSiyao Gao
Siyao Gao
Background: Chronic obstructive pulmonary disease (COPD) is closely linked to cardiovascular diseases. We aimed to investigate the association between Life’s Essential 8 (LE8), the newly established measurement to assess cardiovascular health (CVH), and COPD among U.S. general adults. Methods: This study extracted the National Health and Nutrition Examination Survey (2007–2018) data. Multivariate logistic regression models were used to examine the associations between LE8 and COPD. A restricted cubic spline regression model was used to explore the dose-response relationships between LE8 scores and COPD. In addition, subgroup and sensitivity analyses were performed to assess the robustness of our results. Results: Our study included 19,774 participants representing 145.2 million non-institutionalized U.S. population aged ≥ 20 years. The overall age-adjusted prevalence of COPD was 4.5%. After adjusting for the potential covariates, LE8 was inversely associated with COPD [adjusted odds ratio (AOR) = 0.169, 95% CI: 0.115, 0.249], exhibiting a nonlinear dose-response relationship (P for nonlinearity < 0.05). Similar trends in the associations of health behavior score (AOR = 0.300, 95% CI: 0.223, 0.404) and health factor score (AOR = 0.603, 95% CI: 0.426, 0.852) with COPD were also identified. Furthermore, higher LE8 metric scores of nicotine exposure and sleep health were associated with a lower prevalence of COPD. Conclusion: LE8 was inversely associated with spirometric/self-reported COPD in a nonlinear trend, primarily driven by the nicotine exposure metric of LE8. Adhering to LE8 guidelines, especially smoking cessation, to sustain optimal CVH levels may be beneficial to alleviate the burden of COPD.

21 February 2025 in International Journal of Behavioral Nutrition and Physical Activity
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Journal Article
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YLYuhang Liu
Yuhang Liu
SGSiyao Gao
Siyao Gao
ZDZhigang Dou
Zhigang Dou
ZCZhen Chen
Zhen Chen
JTJialing Tang
Jialing Tang
Background: The relationship between 24-hour (24-h) movement guidelines and frailty remains unclear. We aimed to investigate the associations between meeting 24-h movement guidelines and frailty and to conduct secondary analyses by age, gender, and ethnicity. Methods: In this study, we extracted data from the National Health and Nutrition Examination Survey (2007–2018) database. A total of 5,726 participants (50.25 ± 0.31 years) were included in this analysis, representing 38,240,356 noninstitutionalized U.S. individuals. Three 24-h movement behaviors, namely, physical activity, sedentary behavior (SB), and sleep, were self-reported using the standardized questionnaires. The 49-item frailty index was used to measure frailty. Multivariable logistic regression models and trend tests were used to examine the associations between meeting 24-h movement guidelines and frailty. Sensitivity analyses were also conducted to ensure the robustness of our results. Results: The total age-adjusted prevalence of frailty was 30.5%. In the fully adjusted model, compared with not meeting any of the 24-h movement guidelines, the adjusted odds ratios (AORs) of frailty were 0.786 (95% CI: 0.545, 1.133), 1.161 (95% CI: 0.787, 1.711), and 0.915 (95% CI: 0.616, 1.358) for participants meeting only moderate to vigorous physical activity (MVPA), only SB, and only sleep guidelines, respectively, but no statistically significant differences were observed (all P values > 0.05). Participants who met the SB + sleep guidelines (AOR = 0.613, 95% CI: 0.423, 0.887), MVPA + sleep guidelines (AOR = 0.389, 95% CI: 0.255, 0.593), and MVPA + SB guidelines (AOR = 0.555, 95% CI: 0.383, 0.806) presented a significantly lower risk of frailty by 39%, 61%, and 45%, respectively. Meeting all 3 guidelines (AOR = 0.377, 95% CI: 0.264, 0.539) and meeting 2 guidelines (AOR = 0.527, 95% CI: 0.377, 0.736) were associated with a lower risk of frailty (P value < 0.001), showing a linear trend (P for trend < 0.001). The strength of these associations varied somewhat by age, gender, and ethnicity. Conclusions: Significant associations between the 24-h movement guidelines and frailty were observed among U.S. adults. Future studies are warranted to examine the causality and trajectory of these associations.

1 June 2022 in Diabetes Therapy
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Journal Article
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SGSiyao Gao
Siyao Gao
LYLing Yu
Ling Yu
GYGuozhong Yi
Guozhong Yi
TLTong Li
Tong Li
ZCZhenyin Chen
Zhenyin Chen
JDJiawang Ding
Jiawang Ding
Introduction Sarcopenia is defined as a progressive and generalized muscle disorder that involves accelerated loss of muscle mass and impaired function. It is believed to influence the ability to carry out daily activities, muscle strength, and physical capacity in the elderly. Studies have shown that sarcopenia has been implicated as both a cause and a consequence of diabetes mellitus. In this analysis, we aimed to systematically show the impact of exercise intervention as a therapy for patients with diabetes mellitus and sarcopenia. Methods Electronic databases, including PubMed, EMBASE, Web of Science, and the Cochrane database, were searched from November to December 2021 for publications based on exercise intervention in patients with sarcopenia. After the selection of studies for this analysis, patients with diabetes mellitus were retrieved. Since dichotomous data including mean and standard deviation were reported, weighted mean difference (MD) with 95% confidence intervals (CI) were used to represent the data following analysis. Results A total of 431 participants with diabetes mellitus and sarcopenia were included in this meta-analysis. A statistical analysis was carried out on patients with diabetes mellitus who were assigned to the exercise intervention group. Our analysis showed that “sit-to-stand test” and “timed up and go” were significantly in favor of exercise intervention: MD −1.57, 95% confidence interval (CI) −2.26 to −0.87 (P = 0.0001) versus MD −0.61, 95% CI −1.21 to −0.01 (P = 0.05), respectively. Handgrip strength, walking speed and leg strength were also assessed. Another statistical analysis was carried out, this time on patients with diabetes mellitus and sarcopenia who were not assigned to an exercise intervention. The results showed no significant difference among sit-to-stand test, timed up and go, handgrip strength, and leg strength. Conclusion Exercise intervention significantly improved the time taken to stand up from a sitting position, and to “stand up and go” in patients with diabetes mellitus and sarcopenia. Therefore, exercise intervention should be considered a relevant therapy for such patients.

12 September 2021 in Diabetes Therapy
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Journal Article
Open access
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SGSiyao Gao
Siyao Gao
JTJialing Tang
Jialing Tang
GYGuozhong Yi
Guozhong Yi
ZLZhong Li
Zhong Li
ZCZhenyin Chen
Zhenyin Chen
ZTZhangui Tang
Zhangui Tang
Introduction It has been recommended that physical activity be a part of treatment and management regimens of type 2 diabetes mellitus (T2DM), and research has shown that regular physical exercise facilitates glycemic control in these patients. In this analysis, our aim was to systematically show the therapeutic effects of mild to moderate intensity aerobic exercise on glycemic control in patients with T2DM. Methods From February to April 2021, we searched the https://www.clinicaltrials.gov, EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and Google Scholar databases for trials that showed the effects of aerobic exercise on glycemic control in patients with T2DM. Glycated hemoglobin (HbA1c) was the endpoint in the analysis. The RevMan version 5.4 statistical program was used for statistical analysis, and the mean difference (MD) and 95% confidence intervals (CI) used to represent the data following analysis. Results Eighteen trials involving 972 participants with T2DM were included in this meta-analysis, of whom 523 were assigned to an exercise group and 449 were assigned to a control group. A comparison pre- versus post-aerobic exercise showed that aerobic exercise significantly improved glycemic control (HbA1c) (MD 0.35, 95% CI 0.23–0.48; P = 0.00001) in these patients with T2DM. A second comparison, T2DM participants in the experimental group post-exercise versus T2DM participants from the control group at the end of the follow-up, also showed that aerobic exercise significantly improved glycemic control (MD − 0.46, 95% CI − 0.69 to − 0.22; P = 0.0001). However, a comparison of HbA1c of T2DM participants in the control group at the beginning of the study compared to those at the end of follow-up did not show any significant improvement in glycemic control (MD 0.08, 95% CI − 0.05 to 0.21; P = 0.21). Conclusion The current analysis showed that mild to moderate intensity aerobic exercise significantly improved glycemic control in patients with T2DM. Patients with T2DM who regularly participated in aerobic exercise activities had a better control of their disease than those who were not on a regular aerobic exercise regimen. These results lead to the recommendation that at least mild to moderate intensity aerobic exercise should be included in the treatment and management regimens of patients with T2DM.

28 October 2024 in Frontiers in Endocrinology
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Journal Article
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YLYuhang Liu
Yuhang Liu
JTJialing Tang
Jialing Tang
SGSiyao Gao
Siyao Gao
Background: Metabolic syndrome (MetS) has a close association with cardiovascular diseases. Few studies have investigated the association of Life’s Essential 8 (LE8), the updated measurement of cardiovascular health (CVH), with MetS.Methods: The National Health and Nutrition Examination Survey (2005–2018) data was extracted. The LE8 comprised 4 health behaviors (diet, physical activity, nicotine exposure, and sleep health) and 4 health factors [body mass index (BMI), blood lipids, blood glucose, and blood pressure (BP)]. The total LE8 score is the average of 8 metric scores (0-100), categorized into low (0–49), moderate (50–79), and high CVH (80–100) levels. Multivariable logistic regression models, restricted cubic spline models and stratified analyses were performed to examine the relationship between LE8 and MetS.Results: In this study, a total of 21,543 participants represented 146.6 million non-institutionalized U.S. adults. Following adjustment for various potential covariates, participants who attained a moderate [adjusted odds ratio (AOR) = 0.234, 95% CI: 0.209, 0.262] or a high CVH level (AOR = 0.026, 95% CI: 0.021, 0.032) exhibited an inverse correlation with MetS risks when comparing those with a low CVH level. An inverse linear dose-response relationship between LE8 scores and MetS risks was also identified (P for nonlinearity > 0.05).Conclusions: LE8 was inversely associated with the risk of MetS. Adhering to LE8 guidelines to sustain a higher CVH level may be beneficial for preventing MetS.

1 December 2025 in Humanities and Social Sciences Communications
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Journal Article
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FYFeiran Yang
Feiran Yang
JRJeffrey William Ripley-Gonzalez
Jeffrey William Ripley-Gonzalez
JTJialing Tang
Jialing Tang
SGSiyao Gao
Siyao Gao
Dance therapy integrates movement and dance, enhances emotional, cognitive, and physical health, making it a valuable rehabilitation tool. Dance therapy has been applied to clinical populations, addressing depression, Parkinson’s disease, and dementia. Despite its expanding application in rehabilitation settings, to our knowledge, no prior study has systematically mapped the bibliometric landscape of dance therapy in rehabilitation. This study performed the first longitudinal bibliometric analysis focused on dance therapy in rehabilitation, identifying key research areas, emerging trends, and the evolution of dance therapy’s role in rehabilitation. A systematic search was conducted in the Web of Science Core Collection, yielding 1356 publications from January 1, 2000, to December 31, 2024. Bibliometric analyses were performed using VOSviewer, bibliometrix in R, Scimago, and CiteSpace to construct collaborative networks, perform co-occurrence analyses, and visualize thematic evolutions. The annual number of publications increased significantly over the study period, from three studies in 2000 to 188 in 2024, achieving a compound annual growth rate of 19.34%. A total of 26,254 citations were received by 2024, an average of 19.4 citations per publication. The United States, the United Kingdom, and China emerged as the most productive countries, with notable collaborations among leading institutions such as the University of Haifa and Drexel University. Keyword analyses revealed research hotspots including the efficacy of dance therapy for improving mental health (depression, anxiety), and quality of life through dance therapy, Parkinson’s disease, and neurodegenerative diseases. Emerging trends indicate a growing focus on complementary and alternative medicine approaches within the field. This study shows, dance therapy in rehabilitation has experienced substantial growth and diversification of research themes. Enhanced interdisciplinary cooperation and further exploration of emerging trends are recommended to advance the integration of dance therapy into comprehensive rehabilitation strategies.