Dario Cirillo

Dr. Dario Cirillo

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2024 in Drug Design, Development and Therapy
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ANTONIO COVIELLOANTONIO COVIELLO
ANTONIO COVIELLO
CICarmine Iacovazzo
Carmine Iacovazzo
DCDario Cirillo
Dario Cirillo
ABAlessio Bernasconi
Alessio Bernasconi
AMAnnachiara Marra
Annachiara Marra
GSGiuseppe Servillo
Giuseppe Servillo
Background and Aim: Ultrasound popliteal sciatic nerve block (UPSNB) is commonly performed in foot and ankle surgery. This study aims to assess the use of dexmedetomidine and dexamethasone as adjuvants in UPSNB for hallux valgus (HV) surgery, comparing their efficacy in producing motor and sensory block and controlling postoperative pain. The adverse event rate was also evaluated. Methods: This mono-centric retrospective study included 62 adult patients undergoing HV surgery: 30 patients received lidocaine 2% 200 mg, ropivacaine 0.5% 50 mg and dexamethasone 4 mg (Group 1), whereas 32 patients received lidocaine 2% 200 mg, ropivacaine 0.5% 50 mg, and dexmedetomidine 1 mcg/Kg (Group 2). At first, the visual analogue scale (VAS) was evaluated after 48 hours. The other outcomes were time to motor block regression, evaluation of the first analgesic drug intake, analgesic effect, adverse effects (hemodynamic disorders, postoperative nausea and vomiting (PONV)) and patient satisfaction. The continuous data were analyzed with student’s t-test and the continuous one with χ2. Statistical significance was set at a p-value lower than 0.05. Results: No significant difference was found in VAS after 48 hours (4.5 ± 1.6 vs 4.7 ± 1.7, p = 0.621) to motor block regression (18.9 ± 6.0 vs 18.7 ± 6, p = 0.922). The number of patients that took their first analgesic drug in the first 48 h (p = 0.947 at 6 hours; p = 0.421 at 12 hours; p = 0.122 at 24 hours and p = 0.333 at 48 hours) were not significant. A low and similar incidence of intraoperative hemodynamic disorders was recorded in both groups (hypotension p = 0.593; bradycardia p = 0.881). Neither PONV nor other complication was found. Patients in Group 1 reported a lower degree of interference with sleep (p = 0.001), less interference with daily activities (P = 0.002) and with the affective sphere (P = 0.015) along with a more satisfactory postoperative pain management (p < 0.001) as compared to Group 2. Conclusion: No significant differences were observed in the duration of motor and sensory blockade between patients in both groups. Additionally, both groups showed good pain control with a low rate of adverse effects, even if there was no clinical difference between the groups. However, patients who received dexamethasone reported experiencing less interference with their sleep, daily activities and overall emotional well-being, and overall pain control.

Verified
Journal Article
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ANTONIO COVIELLOANTONIO COVIELLO
ANTONIO COVIELLO
CICarmine Iacovazzo
Carmine Iacovazzo
IPIlaria Piccione
Ilaria Piccione
CPConcetta Posillipo
Concetta Posillipo
MBMARIA SILVIA Barone
MARIA SILVIA Barone
MVmaria vargas
maria vargas
In current practice, single-shot spinal anesthesia has traditionally been performed using the conventional surface-anatomic-Landmark-Guided technique. This “blind” technique has significant critical issues such as a high risk of complications due to the numerous attempts at spinal needle placement and the negative impact on the learning curve of the trainees. Ultrasound-Assisted spinal anesthesia could reduce these critical issues and allow trainees to perform the procedure more easily and with fewer complications for the patient. We performed a before-and-after monocentric retrospective comparative study at the University of Naples “Federico II” (Naples, Italy). Inclusion criteria were as follows: patients aged 18 years or older; ASA physical status between I and IV; and elective orthopedic surgery under single-shot spinal anesthesia performed by supervised trainees between January 2022 and December 2022. In the selected cohort, 88 patients were included in group A (Landmark-Guided spinal anesthesia) and 91 in group B (Ultrasound-Assisted spinal anesthesia). The number of attempts by trainees (p-value < 0.005), procedure performing time (<0.001), and patient discomfort (<0.001) were significantly lower in group B than in group A. Ultrasound-Assisted single-shot spinal anesthesia performed by novice trainees reduces the number of attempts, complication rate, periprocedural pain, and patient discomfort.

19 January 2023 in Techniques in Hand & Upper Extremity Surgery
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Journal Article
Open access
MCMattia Carozzo
Mattia Carozzo
GPGiorgio Pajardi
Giorgio Pajardi
MBMorena Anna Basso
Morena Anna Basso
DCDario Cirillo
Dario Cirillo
Giovanni BalatoGiovanni Balato
Giovanni Balato
FSFrancesco Smeraglia
Francesco Smeraglia
The suture button (SB) suspension technique has become popular in the treatment of thumb basal joint arthritis, as it works as an internal mean for metacarpal stabilization, demonstrating good results with improvement in function and strength. The aim of our study is to describe a new transosseous suture suspensionplasty technique using a simple Ethibond #2 suture as a substitute for the suture button and to report the postoperative clinical outcomes. In this study, we included a total of 14 patients with 2 years follow-up. We evaluated patients with the use of the Disabilities of the Arm, Shoulder and Hand questionnaire, the Visual Analog Scale, the Kapandji test, and the key pinch strength. Patients treated with transosseous suture suspensionplasty demonstrated clinical improvement at an average follow-up of 24 months. No complications were noted immediately after the procedure or during the 2-year follow-up period.

1 September 2025 in Local and Regional Anesthesia
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ANTONIO COVIELLOANTONIO COVIELLO
ANTONIO COVIELLO
GRGiorgio Ranieri
Giorgio Ranieri
FCFilomena Coppola
Filomena Coppola
RDRossella Damonte
Rossella Damonte
DCDario Cirillo
Dario Cirillo
GSGiuseppe Servillo
Giuseppe Servillo
Background and Aim: Interscalene Brachial Plexus Block (ISBPB) is commonly used for shoulder surgery anesthesia to reduce opioid use and general anesthesia complications. However, it may cause diaphragmatic paresis due to phrenic nerve involvement. This study compares the incidence of hemidiaphragmatic paralysis and the frequency of side effects—including hemodynamic changes and postoperative complications—between the Extrafascial (ExF) and Intrafascial (InF) approaches for ISBPB using reduced anesthetic volume. The aim is to assess whether the ExF approach may be preferable in patients with reduced cardiopulmonary reserve (eg, COPD or heart failure). Methods: A retrospective study was conducted at Federico II University in Naples, Italy, including 61 patients undergoing shoulder surgery from January 2024 to October 2024. About 33 patients received ExF while 28 received InF ISBPB, all with Ropivacaine 0.5% (10 mL), Mepivacaine 2% (5 mL), and Dexamethasone (4 mg). The primary outcome was the incidence of hemidiaphragmatic paralysis, evaluated via ultrasound pre and 30 minutes after the block by assessing diaphragm excursion, thickness, and thickening fraction. Secondary outcomes included intraoperative hemodynamic changes and postoperative complications: pain (NRS), analgesic/antiemetic requests, PONV, pruritus, shivering, anxiety, and discomfort. Results: The TF significantly decreased after the block in both groups (p < 0.001), with no intergroup. Diaphragm paralysis occurred in 28 patients in each group (p = 0.093), without clinical respiratory effects. The InF group had more hypotension episodes (100% vs 30.3%, p = 0.002), and significantly lower mean and systolic blood pressure values at 1 and 2 hours after-block. No cases of anxiety, pruritus, shivering, or discomfort were observed. NRS was higher in the InF group at 6 hours but lower at 12 and 24 hours. Analgesic/antiemetic needs were similar; PONV was more frequent in the ExF. Conclusion: Both approaches resulted in similar rates of hemidiaphragmatic paralysis. However, ExF was associated with fewer hemodynamic effects, suggesting potential benefit in high-risk cardiopulmonary patients.

10 January 2025 in Medicina
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Journal Article
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GSGiuseppe Sepolvere
Giuseppe Sepolvere
MTMario Tedesco
Mario Tedesco
MCMario Cibelli
Mario Cibelli
DCDario Cirillo
Dario Cirillo
ASAngelo Sparaco
Angelo Sparaco
ANTONIO COVIELLOANTONIO COVIELLO
ANTONIO COVIELLO
The anatomy of the sciatic nerve allows it to be blocked at different levels using various anesthetic approaches. However, for several reasons, performing these approaches may be challenging or disadvantageous in specific categories of patients, particularly in obese patients. The objective of this brief technical report is to describe a new technical approach to sciatic nerve block, designed to simplify the procedure for certain categories of patients and less experienced practitioners. Since 2010, more than 5000 procedures have been performed by both experienced anesthesiologists and novice trainees in several hospitals. The ultrasound lateral mid-shaft technique appears to be a safe and effective method for performing a sciatic nerve block, even in obese patients with significant subcutaneous fat and unclear ultrasound images. This approach is particularly beneficial given the various anatomical variations that can occur. By targeting the mid-thigh area, the ultrasound beam accesses anatomical structures that are more superficial, improving the technique’s efficacy. Various hospital groups have been performing this technique as a routine procedure, achieving a success rate of nearly 100%. This impressive success rate exceeds that of other conventional techniques documented in the literature. Additionally, there have been significant improvements in comfort and ease for anesthetists. This method allows the anesthetic to spread around the paraneural sheath, covering the posterior femoral cutaneous nerve. Finally, it is performed in the supine position without the need to mobilize the lower limbs, ensuring patient comfort, especially in cases of fractures or lower limb injuries. Further studies are needed to confirm these results.

1 October 2023 in Journal of Pain Research
Verified
Journal Article
Open access
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ANTONIO COVIELLOANTONIO COVIELLO
ANTONIO COVIELLO
CICarmine Iacovazzo
Carmine Iacovazzo
DCDario Cirillo
Dario Cirillo
PDPasquale Diglio
Pasquale Diglio
ABAlessio Bernasconi
Alessio Bernasconi
GSGiuseppe Servillo
Giuseppe Servillo
Introduction: Loco-regional anesthesia role is increasingly important in surgery, especially in postoperative pain control. Using ultrasound-guided techniques has made the loco-regional approach increasingly safe and manageable, guaranteeing excellent analgesic results and patient compliance. This bibliometric research aimed to identify the most influential papers on the adductor canal blocks and outline their characteristics. Methods: All articles published from 1980 to 2022 were included in the Web of Science, PubMed, and Scopus databases and found using the keywords “Adductor canal block” or “Saphenous nerve block” or “Peripheral nerve block” or “Hunter canal block” or “Subsartorial canal block” or “ACB” or “Knee” or “TKR” or “TKA” or “Analgesia” or “Arthroplasty” or “Replacement” in the title section had bibliometric analysis performed. The first 25 papers were selected and analyzed by the number of citations. The correlation between numerical variables was evaluated using the Pearson Correlation coefficient. Results: Literature screening found 252 publications. One hundred ten were only about the adductor canal block. Of these, 25 articles were selected for our bibliometric study, published in 8 different journals and with a total number of citations equal to 1.457. “Regional Anesthesia and pain medicine” journal – with 9 articles – was the one that produced the most. There was a significant strong correlation between the n. of citations and the citation rate (R = 0.84, p < 0.001). Conclusion: The purpose of this study is to be a guide on regional anesthesia and, particularly, on adductor canal block, making the most effective as well as the most cited articles available to anesthesiologists or other researchers interested in this topic.