Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). Background: Remote measurement technology (RMT) offers the opportunity to provide insight and support for self-management of health in real-time. These methods could augment healthcare by providing personalised, precise and pre-emptive interventions. However, for successful implementation users need to be engaged in its use. Objective: This paper provides an overview of the key barriers and facilitators to engagement and use. It is timely as mobile technology such as wearable devices and smartphone applications are becoming increasingly available. Methods: A systematic review using PRISMA guidelines involving original studies dating back to the last systematic review published in 2014. They were included if they met the following PICOS entry criteria. Population: people using RMT approaches to aid management of health; Intervention: RMT system; comparison group: no comparison group specified; outcomes: qualitative and or quantitative evaluation of the barriers and facilitators to engagement with this system; study design: randomized controlled trials (RCT), feasibility studies, and observational studies. Five databases were searched: Ovid MEDLINE, IEEE Xplore, EMBASE, Web of Science and the Cochrane Library, from January 2014 to May 2017). Articles were screened by two researchers, independently. Study characteristics were extracted and a content analysis conducted to define emerging themes to synthesise findings. Formal quality assessments were performed to address risk of bias. Results: Thirty-three publications met inclusion criteria, employing either quantitative, qualitative or mixed-methods designs. Studies were conducted in 10 countries, included men and women, ranging from 8-95 years and included both active and passive remote monitoring systems for a diverse range of physical and mental health conditions. However, they were relatively short and had small sample sizes and reporting of usage statistics was inconsistent. Acceptability of RMT according to the average percentage of time used (64-86.5%) and dropout rates (0-44%) were variable. The barriers and facilitators from the content analysis related to: health status, perceived utility and value, motivation, convenience and accessibility, and usability. These led to the development of a model of barriers and facilitators of engagement with RMT. Conclusions: The hypothesised model of processes that could facilitate RMT engagement may drive the development of more person-focussed RMT, especially if it involves co-design with the target audience. However, it needs further testing through carefully designed experimental studies.