Antimicrobial resistance is a growing global health threat, and artificial intelligence offers a promising avenue for developing advanced tools to address this challenge. In this study, we applied various machine learning techniques to predict bacterial antibiotic resistance using the Pfizer ATLAS Antibiotics dataset. This comprehensive dataset includes patient demographic data, sample collection details, antibiotic susceptibility test results, and resistance phenotypes for 917,049 bacterial isolates. The dataset was divided into two subsets: Phenotype-Only and Phenotype + Genotype, excluding and including 589,998 isolates with genotype data, respectively. Both subsets underwent exploratory data analysis, preprocessing, machine learning model training, validation, and optimization. XGBoost consistently outperformed other models, achieving AUC values of 0.96 and 0.95 for the Phenotype-Only and Phenotype + Genotype sets, respectively. Hyperparameter tuning yielded slight accuracy improvements, while data balancing techniques notably increased recall. Across all models, the antibiotic used emerged as the most influential feature in predicting resistance outcomes. The SHAP summary plots generated provide insights into model interpretability. Our findings provide valuable insights into global AMR patterns and demonstrate the potential of AI-driven approaches for resistance prediction to help inform clinical decision-making and support the formulation of effective AMR mitigation policies, subject to the availability of highly granular datasets.

Background: Modern data-driven medical research provides new insights into the development and course of diseases and enables novel methods of clinical decision support. Clinical and translational data warehouses, such as Informatics for Integrating Biology and the Bedside (i2b2) and tranSMART, are important infrastructure components that provide users with unified access to the large heterogeneous data sets needed to realize this and support use cases such as cohort selection, hypothesis generation, and ad hoc data analysis. Objective: Often, different warehousing platforms are needed to support different use cases and different types of data. Moreover, to achieve an optimal data representation within the target systems, specific domain knowledge is needed when designing data-loading processes. Consequently, informaticians need to work closely with clinicians and researchers in short iterations. This is a challenging task as installing and maintaining warehousing platforms can be complex and time consuming. Furthermore, data loading typically requires significant effort in terms of data preprocessing, cleansing, and restructuring. The platform described in this study aims to address these challenges. Methods: We formulated system requirements to achieve agility in terms of platform management and data loading. The derived system architecture includes a cloud infrastructure with unified management interfaces for multiple warehouse platforms and a data-loading pipeline with a declarative configuration paradigm and meta-loading approach. The latter compiles data and configuration files into forms required by existing loading tools, thereby automating a wide range of data restructuring and cleansing tasks. We demonstrated the fulfillment of the requirements and the originality of our approach by an experimental evaluation and a comparison with previous work. Results: The platform supports both i2b2 and tranSMART with built-in security. Our experiments showed that the loading pipeline accepts input data that cannot be loaded with existing tools without preprocessing. Moreover, it lowered efforts significantly, reducing the size of configuration files required by factors of up to 22 for tranSMART and 1135 for i2b2. The time required to perform the compilation process was roughly equivalent to the time required for actual data loading. Comparison with other tools showed that our solution was the only tool fulfilling all requirements. Conclusions: Our platform significantly reduces the efforts required for managing clinical and translational warehouses and for loading data in various formats and structures, such as complex entity-attribute-value structures often found in laboratory data. Moreover, it facilitates the iterative refinement of data representations in the target platforms, as the required configuration files are very compact. The quantitative measurements presented are consistent with our experiences of significantly reduced efforts for building warehousing platforms in close cooperation with medical researchers. Both the cloud-based hosting infrastructure and the data-loading pipeline are available to the community as open source software with comprehensive documentation.

With the unprecedented rise in the number of IoT devices, the amount of data generated from sensors is huge and often demands an in-depth analysis to acquire suitable insights. Mashup tools, used primarily for intuitive graphical programming of IoT applications, can help both for efficiently prototyping and also data analytics pipelines. In this study, we focus on the tight integration of data analytics capabilities of Spark in IoT mashup tools. The main challenge in this direction is the presence of a wide range of data interfaces and APIs in the Spark ecosystem. In this study, we contribute to current applications by (i) providing a thorough analysis of the Spark ecosystem and selecting suitable data interfaces for use in a graphical flow-based programming paradigm, (ii) devising a novel, generic approach for programming Spark from graphical flows that comprises early-stage validation and code generation of Java Spark programs. The approach is implemented in aFlux, our JVM-based mashup tool and is evaluated in three use cases showcasing the machine learning and stream analytics capabilities of Spark.

Indoor localization is used to locate objects and people within buildings where outdoor tracking tools and technologies cannot provide precise results. This paper aims to improve analytics research, focusing on data collected through indoor localization methods. Smart devices recurrently broadcast automatic connectivity requests. These packets are known as Wi-Fi probe requests and can encapsulate various types of spatiotemporal information from the device carrier. In addition, in this paper, we perform a comparison between the Prophet model and our implementation of the autoregressive moving average (ARMA) model. The Prophet model is an additive model that requires no manual effort and can easily detect and handle outliers or missing data. In contrast, the ARMA model may require more effort and deep statistical analysis but allows the user to tune it and reach a more personalized result. Second, we attempted to understand human behaviour. We used historical data from a live store in Dubai to forecast the use of two different models, which we conclude by comparing. Subsequently, we mapped each probe request to the section of our place of interest where it was captured. Finally, we performed pedestrian flow analysis by identifying the most common paths followed inside our place of interest.