Based on the resource orchestration theory, this study built a research model to understand the effect of supply chain network insight and supply chain integration on enterprise performance. We also involved the contingency theory to investigate the moderating effect of environmental uncertainty on supply chain integration and enterprise performance. We collected the data samples from 405 enterprises and used the SEM approach to verify the model. Results demonstrated the direct path of network insight to promote enterprise performance, the indirect path of supply chain integration as a mediating factor, and the role of environmental uncertainty as a boundary condition for the relationship between supply chain integration and enterprise performance, thus making theoretical and practical contributions to the management of supply chain resources and relationships and the performance enhancement of manufacturing.