Background: Breast carcinoma (BC) is a cancer with a high morbidity rate, but the mechanisms by which it develops are never clear. There has been speculation regarding the potential relationships between breast cancer and local HPV infections for some time, and although much clinical research supports this hypothesis, some research results disprove the association. Therefore, the association is still inconclusive. Methods: We performed the data collection by searching the database PubMed, Embase, Cochrane Library and Web of science. In addition, 22 sites were added manually. After carefully selection, the pooled odds rate of 37 included case control studies was calculated. Subgroup analysis, publication bias and trim & fill analysis were conducted to make the result more reliable. Results: The analysis of 37 case control studies containing 3,607 BC cases and 1,728 controls showed obviously increase of BC risk with human papillomavirus (HPV) positive [summary odds ratio (SOR) =6.22, 95% confidence interval 4.25 to 9.12; P=0.0002]. Subgroup analysis proved three high risk HPV types (HPV16, 18 and 33) were positively correlated to BC. Conclusions: This systemic review and meta-analysis provide the evidence for HPV infection as a potential risk factor in BC, while the mechanism of this hypothesis still needs further evaluation.

Background: The 2020 coronavirus pandemic (COVID-19) has been raging for more than 20 months, putting significant strain on public health systems around the world. Despite the fact that the pandemic has been effectively managed in certain countries, regional outbreaks and viral mutations continue to pose a threat to people's lives. The likelihood of post-pandemic changes in people's psychological situations warrants more investigation. Design and participants: This study was conducted in the context of another outbreak in Zhangjiajie, China, respondents (infected patients, healthy population) were required to complete self-administered questions and standardized questionnaires, including the patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder-7 (GAD-7), and the Brief Illness Perception Questionnaire (BIPQ). Measures: We conducted an anonymous questionnaire survey of infected patients (excluding critically ill patients) in the confirmed COVID-19 ward of Zhangjiajie City People's Hospital's East Hospital from August 14 to 24, 2021, and used convenience sampling to survey medical staff and the general public to assess the psychological reactions of different populations during the delta variant outbreak pandemic. Differences in anxiety and depression severity were compared between groups, with logistic regression models constructed to explore potential factors associated with scoring clinical significant levels of depression and/or anxiety. Results: There is no significant difference (p value = 0.228) between anxiety and depression in patients (n = 53), general public (n = 97), medical personnel (n = 103), and support workers (n = 65). Females reported higher scores on the GAD-7 and the BIPQ, reduced communication with family and friends appeared to be a risk factor for clinically significant anxiety and depression. Conclusions: There were no significant differences in anxiety and depression across populations explored in this study, but females had higher anxiety and illness perception than males, and effective communication may help improve mental health.

Introduction: In July 2021, Zhangjiajie City became the new epicenter of the COVID-19 outbreak. Aside from the physical manifestations of COVID-19, patients are also victims of severe social stigmatization. Stigma affects not only COVID-19 patients or survivors, but also individuals associated with them. This study aims to describe and assess the COVID-19-related stigma between patients, their relatives, and healthy local residents.Methods: The study included 43 COVID-19 patients, 68 relatives, and 75 healthy residents from Zhangjiajie. Demographic data was collected, including gender, age, marital status, and educational level. Stigma attitudes toward COVID-19 were measured using the Stigma Scale and Social Distance Scale. Frequencies and percentages were described for each item of the scales, and differences among the three groups were examined using the chi-square test.Results: With regards to personal and perceived stigma, most participants agreed that patients with COVID-19 “could snap out of the problem” and that “they were dangerous.” For social distance, over 30% of participants from the three groups agreed with the item “unwillingness to marry into the family of someone with COVID-19.” In all groups, there were significant statistical differences in the belief that “the problem is not a real medical illness” and the desire to “spend the evening socializing.”Conclusion: Although the outbreak was well-contained in Zhangjiajie, stigmatizing attitudes toward COVID-19 and desire for social distance to such patients were common among patients, their relatives and healthy local residents. Our study's results suggest that public education, anti-stigma interventions, and policies are necessary for people living in Zhangjiajie in order to effectively curtail the spread of COVID-19 and provide a useful strategy for a tourist city like Zhangjiajie to recover sooner from economic decline.

Objective This study aimed to investigate the impact of "Remote continuity of care intervention model " on the follow-up of postoperative thyroid cancer patients. Methods Between November 2021 and August 2022, a total of 404 thyroid cancer patients, who had undergone surgical treatment in the Department of Thyroid Surgery at a comprehensive tertiary-level hospital in Changsha, were randomly assigned to either the experimental group or the control group, with each group consisting of 202 cases. The experimental group adopted the " Remote continuity of care intervention model " for follow-up, while the control group followed traditional nursing procedures. Self-Rating Anxiety Scale, Self-rating Depression Scale, EORTC Quality of Life Questionnaire, adverse reactions, and patient satisfaction were compared between the two groups before and after 3 months of intervention. Results Of the 202 patients in the experimental group and 202 patients in the control group who completed the study, no significant differences were observed in general information, SAS, SDS scores, and dimensions of quality of life before the intervention (P༞0.05). After the intervention, the experimental group exhibited: 1. Lower anxiety and depression levels, with total SAS and SDS scores significantly lower than those of the control group (P < 0.05). 2. Improved quality of life, with higher scores in cognitive, emotional, somatic, social, and role functioning dimensions compared to the control group (P < 0.05). 3. Fewer adverse reactions, with significantly lower rates of panic, excessive sweating, digestive function abnormalities, and no abnormal symptoms in the experimental group (P < 0.05). There were no statistically significant differences in adverse reactions in the form of insomnia, fatigue, weakness, and numbness of the limbs (P > 0.1). Conclusion " Remote continuity of care intervention model " can effectively reduce anxiety and depression levels in post-surgical thyroid cancer patients, lower the incidence of adverse reactions, and enhance overall patient quality of life.