Background: Plyometric training is an effective training method to improve explosive strength. However, the ability to perform plyometric training in the adolescent population is still controversial, with insufficient meta-analyses about plyometric training on lower limb explosive strength in adolescent athletes. Objective: To investigate the influence of plyometric training on the explosive strength of lower limbs in adolescent athletes. Methods: We performed a search of six databases (Web of Science, PubMed, Scopus, ProQuest databases, China National Knowledge Infrastructure (CNKI), and Wan-fang database) from the starting year of inclusion in each database to April 4, 2022. The quality of the included literature was assessed using the Cochrane risk assessment tool, and data were analyzed using the Review Manager 5.4 software. Result: Plyometric training had significant effects on the performance of adolescent athletes in countermovement jump (MD = 2.74, 95% CI: 1.62, 3.85, p < 0.01), squat jump (MD = 4.37, 95% CI: 2.85, 5.90, p < 0.01), standing long jump (MD = 6.50, 95% CI: 4.62, 8.38, p < 0.01), 10-m sprint (MD = −0.04, 95% CI: −0.08, −0.00, p = 0.03), and 20-m sprint (MD = −0.12, 95% CI: −0.20, −0.04, p = 0.03); all had positive and statistically significant effects (p < 0.05). Conclusion: Plyometric training can significantly enhance the explosive strength of lower limbs in adolescent athletes.