The research of Dr. Diren Beyoğlu has primarily focused on clinical applications of metabolomics and lipidomics in the areas of hepatology and oncology. She published the conceptualizing of the glycine deportation system, where it was hypothesized that glycine conjugation of aromatic acids, such as benzoic acid, was not in fact a means of eliminating these acids from the body, but rather these acids were used as a means of regulating glycine homeostasis, through its removal by conjugation and ultimate urinary excretion; the first report of integrated metabolomics and transcriptomics in hepatocellular carcinoma (HCC); first report of the effect on lipid signaling molecules of the inactivation of a tumor suppressor gene in that tissue (Hint1 in the liver); first report of the induction of the polyol pathway in patients infected with Hepatitis C virus, with implications for progression to HCC; first report of the detailed lipidomic landscape of acute myeloid leukemia, a disease known to display perturbations in lipid metabolism; first report of the induction of the Warburg effect in gamma irradiated cells in vitro; first report of the use of robust regression analysis in bioinformatics applied to metabolomics.