Oscillating water column (OWC) systems are among the most credited solutions for an effective conversion of the notable energy potential conveyed by sea waves. Despite a renewed interest, however, they are often still at a demonstration phase and additional research is required to reach industrial maturity. Within this framework, this study provides a wave-to-wire model for OWC systems based on an impulse air turbine. The model performs a comprehensive simulation of the system to estimate the attendant electric energy production for a specific sea state, based on analytical models of the primary (fixed chamber) and secondary (air turbine) converters coupled with the tertiary converter (electric generator). A rigid piston model is proposed to solve the hydrodynamics, thermodynamics, and hydrodynamics of the chamber, in a coupled fashion with the impulse turbine aerodynamics. This is solved with a novel method by considering the cascades as sets of blades, each one consisting of a finite number of airfoils stacked in the radial direction. The model was applied for two Mediterranean sites located in Tuscany and Sardinia (Italy), which were selected to define the optimal geometry of the turbine for a specified chamber. For each system, the developed analytical wave-to-wire model was applied to calculate the performance parameters and the annual energy production in environmental conditions typical of the Mediterranean Sea. The selected impulse turbines are able to convert 13.69 and 39.36 MWh/year, with an efficiency of 4.95% and 4.76%, respectively, thus proving the interesting prospects of the technology.