Two-dimensional (2D) materials, an electrifying family of innovative materials, have recently attracted wide attention due to their remarkable characteristics, primarily their high optical transparency, exceptional metallic conductivity, high mechanical strength, carrier mobility, tunable band gap values, and optimum work function. Interestingly, 2D-nanosheets/nanolayers (2D-NLs) might be synthesized into single/multi-layers using simple processes such as chemical vapor deposition (CVD), chemical bath deposition (CBD), and mechanical and liquid-phase exfoliation processes that simply enhance optoelectronic properties. However, the stability of 2D-NLs is one of the most significant challenges that limits their commercialization. Researchers have been focusing on the stability of 2D-NLs with the aim of developing next-generation solar cells. Easily tunable distinctive 2D-NLs that are based on the synthesis process, surface functional groups, and modification with other materials/hybrid materials thereby improve the stability of the 2D-NLs and their applicability to the hole transport layer (HTL) and the electron transport layer (ETL) in solar cells. Moreover, metal/non-metal-based dopants significantly enhance band gap ability and subsequently improve the efficacy of dye-sensitized solar cells (DSSCs). In this context, research has focused on 2D-NL-based photoanodes and working electrodes that improve the photoconversion efficiency (PCE) and stability of DSSCs. Herein, we mainly focus on synthesizing 2D-NLs, challenges during synthesis, stability, and high-performing DSSCs.