To overcome the spread of the severe COVID-19 outbreak, various lockdown measures have been taken worldwide. China imposed the strictest home-quarantine measures during the COVID-19 outbreak in the year 2020. This provides a valuable opportunity to study the impact of anthropogenic emission reductions on air quality. Based on the GEE platform and satellite imagery, this study analyzed the changes in the concentrations of NO₂, O₃, CO, and SO₂ in the same season (1 February–1 May) before and after the epidemic control (2019–2021) for 16 typical representative cities of China. The results showed that NO₂ concentrations significantly decreased by around 20–24% for different types of metropolises, whereas O₃ increased for most of the studied metropolises, including approximately 7% in megacities and other major cities. Additionally, the concentrations of CO and SO₂ showed no statistically significant changes during the study intervals. The study also indicated strong variations in air pollutants among different geographic regions. In addition to the methods in this study, it is essential to include the differences in meteorological impact factors in the study to identify future references for air pollution reduction measures.