Background: Cancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment. Methods: Using data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identify trends and disparities. Results: In 2022, Europe recorded 4,471,422 new cancer cases (ASR 280 per 100,000), with a cumulative risk of 27.9% by age 75. Males accounted for 2,359,303 cases (ASR 319.6, cumulative risk 31.9%), while females had 2,112,119 cases (ASR 253.4, cumulative risk 24.7%). Northern and Western Europe had the highest incidence rates, with Denmark leading at 374.7 per 100,000 (cumulative risk 34.9%), likely due to advanced screening and healthcare. Conversely, Eastern Europe had the highest mortality, with 1,091,871 deaths (ASR 135.3), reflecting late diagnoses and limited access of treatment. Hungary exhibited the highest mortality rate (ASR 143.7, cumulative risk 15.8%), followed by Poland (ASR 133.1). Prostate and breast cancers were the most common in males and females, respectively. Lung cancer, despite a lower incidence (ASR 24.7), had the highest mortality (ASR 17.7), while pancreatic cancer showed high fatality (ASR 6.3, mortality ASR 5.6). Thyroid cancer had a relatively high incidence (ASR 7.5) but low mortality (ASR 0.21). Conclusions: Significant regional disparities in cancer burden underscore the need for targeted public health strategies. Expanding cancer screening programs, strengthening smoking cessation and HPV vaccination efforts, and improving healthcare accessibility particularly in Eastern Europe are critical to reducing mortality and enhancing early detection. Differences in mortality-to-incidence ratios also highlight the role of healthcare infrastructure and timely interventions. Future research should explore the socioeconomic and environmental determinants driving these disparities to inform evidence-based cancer control policies across Europe.

Background: Cryptosporidiosis is a disease caused by infection with an intestinal coccidian parasite Cryptosporidium. Cryptosporidium species are the second leading cause of diarrheal disease and death in children in developing countries. Until now, no data have been available or published on its prevalence among children with diarrhea in Sudan. Therefore, this paper was designed to determine the prevalence rate of Cryptosporidium among children with diarrhea under 5 years who were admitted to Kosti Teaching Hospital. Methods: A hospital-based cross-sectional study including children under 5 years old admitted to the pediatric section of the hospital between September 2020 and December 2020. A total of one-hundred and fifty stool samples were collected. All stool samples were examined using the modified Ziehl Neelsen (mZN) staining technique and then examined microscopically for Cryptosporidium infection. Results: A total of 150 children were examined out of which 70 presented with diarrhea. A greater prevalence of 19/70 (27.1%) of Cryptosporidium was observed in children with diarrhea than children without diarrhea 7/80 (8.8%). There was a significant relationship between the prevalence of Cryptosporidium and the presence of diarrhea in children under 5 years in the Kosti Teaching Hospital(P < 0.05). It was found that a higher prevalence was registered among children using piped-water sources for drinking. Conclusions: The overall prevalence of parasite detected was 17.3% among children admitted to Kosti Teaching Hospital. The prevalence rate of the infection among Children with diarrhoea was 27.1%. Studying the prevalence rate of cryptosporidiosis among diarrheic children may predict their health status, leading to a better diagnosis, treatment, and, therefore, patients’ status improvement.

Background: Rare cancers, defined as those with an incidence rate of fewer than 6 cases per 100,000 individuals, contribute to a substantial portion of the global cancer burden. Despite their impact, they receive less attention than more common malignancies, leading to challenges in early detection, treatment strategies, and research funding. This study aims to assess the global incidence and mortality patterns of rare cancers in 2022 to better understand their contribution to the overall cancer burden and regional disparities. Methods: We conducted a comprehensive analysis using 2022 GLOBOCAN estimates to assess the global incidence and mortality of rare cancers. The study included 24 major rare cancers, such as bladder cancer, leukemia, non-Hodgkin lymphoma, esophageal cancer, and pancreatic cancer. Age-standardized rates (ASRs) were calculated to compare cancer burden across continents, and absolute case and death counts were reported. Results: In 2022, rare cancers accounted for 26.7% of all new cancer cases (5,347,784 cases) and 30% of all cancer-related deaths (2,959,369 deaths) worldwide. Bladder cancer was the most common rare cancer, with an incidence rate of 5.58 per 100,000, followed by non-Hodgkin lymphoma (5.57) and leukemia (5.26). Mortality rates were highest for pancreatic, esophageal, and brain cancers, reflecting their aggressive nature and limited treatment options. Significant regional disparities were observed, with Europe and North America reporting the highest incidence rates for bladder cancer and leukemia, while Asia bore the largest absolute burden of rare cancers. Conclusions: Rare cancers represent a considerable share of the global cancer burden, with notable geographic variations in incidence and mortality. These findings underscore the need for improved early detection, expanded treatment access, and targeted research efforts to address disparities and improve outcomes for patients with rare cancers worldwide.

Background: Individuals with intellectual disabilities (IDs) face unique challenges in accessing cancer prevention measures. Caregivers play a crucial role in facilitating these measures, yet their perspectives are under-researched. Methods: This systematic literature review explores caregiver perspectives on cancer prevention for adults with IDs in institutional and home care settings, aiming to understand their roles, knowledge, and challenges. Thirteen articles from the UK, the USA, Canada, and Ireland were analyzed through thematic synthesis. Four overarching themes were identified: breast cancer screening perspectives, caregivers’ knowledge and barriers to cancer prevention, caregivers’ perspectives, and cultural context and decision-making. Results: Caregivers, including healthcare professionals and family members, are essential in facilitating breast cancer screening for individuals with IDs. Challenges include explaining screening procedures, limited awareness, and logistical barriers, highlighting the need for targeted educational interventions. Disparities in access underscore the necessity for comprehensive training programs. Healthcare professionals’ perspectives reveal existing disparities and suggest interventions for improved accessibility and understanding. Cultural context influences decision-making, emphasizing the importance of culturally sensitive care. The role of family caregivers in decision-making necessitates empowering and supporting them through tailored interventions. Conclusions: This review provides insights into the challenges and opportunities in cancer prevention for individuals with IDs, suggesting the need for educational interventions, training programs, and systemic changes to address disparities. It lays the groundwork for future research and the development of holistic and inclusive strategies in this critical healthcare domain.

Natural resource management (NRM) plays a pivotal role in ensuring the sustainability of ecosystems, which are essential for human health and well-being. This systematic review examines the impact of various NRM practices on water quality and their subsequent effects on public health. Specifically, it focuses on interventions such as watershed management, pollution control, land use management, water treatment, and ecosystem restoration. We conducted a comprehensive search across PubMed, Scopus, and Web of Science, supplemented by gray literature from Google Scholar, WHO reports, and government and NGO publications, covering studies published between 2014 and 2024. A total of 42 studies met the inclusion criteria, encompassing diverse geographical regions with significant representation from developing countries. The findings indicate that effective NRM practices, particularly those aimed at reducing pollutants, managing watersheds, and promoting sustainable land use, significantly improve water quality by lowering levels of chemical contaminants, microbial pathogens, and physical pollutants. Improved water quality directly correlates with reduced incidences of waterborne diseases, chronic health conditions from long-term chemical exposure, and acute health effects from immediate pollutant exposure. The review underscores the need for tailored NRM strategies that consider local environmental and socio-economic contexts. It also highlights the importance of community involvement, regulatory frameworks, and continuous monitoring to enhance the effectiveness of NRM interventions. Despite the positive impacts, barriers such as limited financial resources, technical expertise, and community engagement pose challenges to the implementation of these practices. In conclusion, the systematic review demonstrates that comprehensive and context-specific NRM practices are crucial for improving water quality and public health outcomes. Policymakers and practitioners are encouraged to adopt integrated water resource management approaches, prioritize sustainable practices, and engage local communities to achieve long-term health and environmental benefits.

Background: Cancer awareness and screening among individuals with intellectual disabilities face unique challenges. To bridge this gap, educational interventions have been developed. Aims: This review comprehensively analyzes educational interventions aimed at enhancing cancer awareness among individuals with intellectual disabilities (IDs). It addresses key questions regarding intervention types and effectiveness, influencing factors, and recommendations for impactful programs. Methods and procedures: A robust search strategy was deployed across reputable databases yielding 2512 articles. After meticulous screening and eligibility assessments, eight studies met the inclusion criteria, encompassing qualitative research, a feasibility study, and randomized control trials. Outcomes and results: The studies employed diverse interventions and assessment methods, leading to varying outcomes. Interventions included educational materials, communication packs, health education DVDs, and healthcare professional support, typically delivered over a short period with limited follow-up. Assessment methods comprised surveys, interviews, and knowledge surveys. However, a comprehensive evaluation of knowledge gains and screening uptake was often absent. While some studies reported modest increases in knowledge, none measured actual screening uptake and long-term effects. The strengths and limitations of these studies underscore the need for more comprehensive research in this area, considering factors such as sample size, study design, and long-term impact. Conclusion and implications: In conclusion, this review provides valuable insights into educational interventions for cancer awareness among individuals with intellectual disabilities. Its comprehensive methodology and findings underscore the significance of tailoring interventions, extending their duration, and involving caregivers to optimize outcomes for this vulnerable population.