The paper presents a new approach to the location of fault in the high-voltage power transmission line, relying on the application of the support vector machine and frequency characteristics of the measured one-terminal voltage and current transient signals of the system. The extensive numerical experiments performed for location of different kinds of faults of the transmission line have proved very good accuracy of fault location algorithm. The average error of fault location in a 200-km transmission line is below 100 m and the maximum error did not exceed 2 km.

Cebranopadol (a.k.a. GRT-6005) is a dually acting nociceptin/orphanin FQ and opioid receptor agonist that has been recently developed in Phase 2 clinical trials for painful diabetic neuropathy or cancer pain. It also showed analgesic properties in various rat models of pain and had a better safety profile as compared to equi-analgesic doses of morphine. Since antinociceptive properties of cebranopadol have been studied mainly in rat models, in the present study, we assessed analgesic activity of subcutaneous cebranopadol (10 mg/kg) in various mouse pain models.