Mirjana Zlatkovic-Svenda

Prof. Dr. Mirjana Zlatkovic-Svenda

orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 March 2022 in Annals of the Rheumatic Diseases
Verified
Journal Article
Closed access
PDF file
JGJames M Gwinnutt
James M Gwinnutt
MWMaud Wieczorek
Maud Wieczorek
ABAndra Balanescu
Andra Balanescu
HBHeike A Bischoff-Ferrari
Heike A Bischoff-Ferrari
ABAnnelies Boonen
Annelies Boonen
SVSuzanne M M Verstappen
Suzanne M M Verstappen
Objectives A European League Against Rheumatism taskforce was convened to review the literature and develop recommendations on lifestyle behaviours for rheumatic and musculoskeletal diseases (RMDs). Methods Six lifestyle exposures (exercise, diet, weight, alcohol, smoking, work participation) and seven RMDs (osteoarthritis, rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, gout) were considered. The taskforce included health professionals in rheumatology, geriatricians, epidemiologists, public health experts, people with RMDs and exposure domain experts. Systematic reviews were conducted to gather available evidence, from which recommendations were developed. Results Five overarching principles and 18 specific recommendations were defined based on available evidence. The overarching principles define the importance of a healthy lifestyle, how lifestyle modifications should be implemented, and their role in relation to medical treatments. Exercise recommendations highlight the safety and benefits of exercise on pain and disability, particularly among people with osteoarthritis and axial spondyloarthritis. The diet recommendations emphasise the importance of a healthy, balanced diet for people with RMDs. People with RMDs and health professionals should work together to achieve and maintain a healthy weight. Small amounts of alcohol are unlikely to negatively affect the outcomes of people with RMDs, although people with rheumatoid arthritis and gout may be at risk of flares after moderate alcohol consumption. Smokers should be supported to quit. Work participation may have benefits on RMD outcomes and should be discussed in consultations. Conclusions These recommendations cover a range of lifestyle behaviours and can guide shared decision making between people with RMDs and health professionals when developing and monitoring treatment plans.

31 March 2022 in RMD Open
Verified
Journal Article
Open access
PDF file
JGJames M Gwinnutt
James M Gwinnutt
MWMaud Wieczorek
Maud Wieczorek
GCGiulio Cavalli
Giulio Cavalli
ABAndra Balanescu
Andra Balanescu
HBHeike A Bischoff-Ferrari
Heike A Bischoff-Ferrari
SVSuzanne M M Verstappen
Suzanne M M Verstappen
Background A European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs. Methods Three systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013–2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases. Results 236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies. Conclusion The current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs.

29 March 2022 in RMD Open
Verified
Journal Article
Open access
PDF file
MWMaud Wieczorek
Maud Wieczorek
JGJames Martin Gwinnutt
James Martin Gwinnutt
MRMaxime Ransay-Colle
Maxime Ransay-Colle
ABAndra Balanescu
Andra Balanescu
HBHeike Bischoff-Ferrari
Heike Bischoff-Ferrari
FGFrancis Guillemin
Francis Guillemin
Background A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). The aim of this paper was to review the literature on the relationship between smoking and alcohol consumption with regard to RMD-specific outcomes. Methods Two systematic reviews were conducted to identify systematic reviews and meta-analyses, published between 2013 and 2018, related to smoking and alcohol consumption in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), systemic sclerosis (SSc) and gout. Two additional systematic reviews were performed to identify original longitudinal studies on smoking and alcohol consumption and disease-specific outcomes. Results Nine reviews and 65 original studies on smoking as well as two reviews and 14 original studies on alcohol consumption met the inclusion criteria. While most studies were moderate/poor quality, smoking was significantly associated with poorer outcomes: cardiovascular comorbidity; poorer response to RA treatment; higher disease activity and severity in early RA; axSpA radiographic progression. Results were heterogeneous for OA while there was limited evidence for PsA, SSc and gout. Available studies on alcohol mainly focused on RA, reporting a positive association between alcohol intake and radiographic progression. Five studies assessed alcohol consumption in gout, reporting a significant association between the number and type of alcoholic beverages and the occurrence of flares. Conclusion Current literature supports that smoking has a negative impact on several RMD-specific outcomes and that moderate or high alcohol consumption is associated with increased risk of flares in RA and gout.

2 June 2022 in RMD Open
Verified
Journal Article
Open access
PDF file
JGJames M Gwinnutt
James M Gwinnutt
MWMaud Wieczorek
Maud Wieczorek
JRJavier Rodríguez-Carrio
Javier Rodríguez-Carrio
ABAndra Balanescu
Andra Balanescu
HBHeike A Bischoff-Ferrari
Heike A Bischoff-Ferrari
SVSuzanne M M Verstappen
Suzanne M M Verstappen
Background A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). In this paper, the literature on the effect of diet on the progression of RMDs is reviewed. Methods Systematic reviews and meta-analyses were performed of studies related to diet and disease outcomes in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus, axial spondyloarthritis, psoriatic arthritis, systemic sclerosis and gout. In the first phase, existing relevant systematic reviews and meta-analyses, published from 2013 to 2018, were identified. In the second phase, the review was expanded to include published original studies on diet in RMDs, with no restriction on publication date. Systematic reviews or original studies were included if they assessed a dietary exposure in one of the above RMDs, and reported results regarding progression of disease (eg, pain, function, joint damage). Results In total, 24 systematic reviews and 150 original articles were included. Many dietary exposures have been studied (n=83), although the majority of studies addressed people with OA and RA. Most dietary exposures were assessed by relatively few studies. Exposures that have been assessed by multiple, well conducted studies (eg, OA: vitamin D, chondroitin, glucosamine; RA: omega-3) were classified as moderate evidence of small effects on disease progression. Conclusion The current literature suggests that there is moderate evidence for a small benefit for certain dietary components. High-level evidence of clinically meaningful effect sizes from individual dietary exposures on outcomes in RMDs is missing.

28 July 2017 in BMJ Open Sport & Exercise Medicine
Verified
Journal Article
Open access
PDF file
TDTijana Durmic
Tijana Durmic
BPBiljana Lazovic Popovic
Biljana Lazovic Popovic
MZMirjana Zlatkovic-Svenda
Mirjana Zlatkovic-Svenda
MDMarina Djelic
Marina Djelic
VZVladimir Zugic
Vladimir Zugic
RLRoman Leischik
Roman Leischik
Background/aim: To assess and compare measured ventilatory volumes (forced expiratory volume in 1 s (FEV1), peak expirium flow (PEF) and maximal voluntary ventilation (MVV)), ventilatory function capacities (forced vital capacity (FVC) and vital capacity (VC)) and FEV1/VC ratio in a sample of power and endurance elite athletes and their age-matched and sex-matched sedentary control group. Methods: A cross-sectional study was applied on male elite athletes (n=470) who were classified according to the type of the predominantly performed exercise in the following way: group 1: endurance group (EG=270), group 2: power athletes group (SG=200) and group 3: sedentary control group (CG=100). The lung VC, FVC, FEV1, FEV1/FVC ratio, PEF and MVV were measured in all of the observed subjects, who were also classified with regard to body mass index (BMI) and the percentage of the body fat (BF%). Results: The CG had the highest BF% value, while the endurance group had the lowest BMI and BF% value, which is significantly different from the other two groups (p<0.05). The observed values of VC, FVC and FEV1 in the EG were significantly higher than those from the other two groups (p<0.05). There were no differences concerning the observed FEV1/FVC ratio. Conclusions: A continued endurance physical activity leads to adaptive changes in spirometric parameters (VC, FVC and FEV1), highlighting the fact that there is a need for specific consideration of different respiratory ‘pattern’ development in different types of sport, which also has to be further evaluated.

30 May 2016 in Revista Portuguesa de Pneumologia (English Edition)
Verified
Journal Article
Open access
BLBiljana Lazovic
Biljana Lazovic
MZMirjana Zlatkovic-Svenda
Mirjana Zlatkovic-Svenda
TDT. Durmic
T. Durmic
MDM. Djelic
M. Djelic
SSS. Djordjevic Saranovic
S. Djordjevic Saranovic
VZV. Zugic
V. Zugic
Physical activity has a positive effect on the function of the whole human body system. The influence of physical activity on the development of the respiratory system is still a matter for debate. Swimming is considered the sport with the most profound effect on the lungs. The first aim was to determine pulmonary function and to correlate it with anthropometric features of sportsmen, represented by land- and the water-based elite athletes comparing with their sedentary counterparts; the second aim was to examine whether the training factors (frequency and amount) influence pulmonary function in swimmers, when controlled for anthropometric features. Thirty-eight elite male swimmers were matched for age and sex with two hundred and seventy-one elite football players and one hundred controls who were not involved in any routine exercise. Lung volumes were recorded by Pulmonary Function test and analyzed statistically. Swimmers had statistically higher values of VC, FVC, FEV1 and FEV1/FVC when compared to both the football players and the controls, as the latter two showed no in-between differences. There was significant positive correlation between age, body weight and body height and each of the above named pulmonary parameters, when presented separately for swimmers, football players and the control group. When controlled for the anthropometric features, larger lung volumes in swimmers were not influenced by training period, age at the beginning of training and weekly extent of personal training. Further comprehensive longitudinal studies are needed to confirm these observations.