Jiri Kassa

Prof. Jiri Kassa

orcid

Research Focus & Metrics

Academic Career Length

31Years (1996-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2002 in Journal of Toxicology: Clinical Toxicology
Verified
Journal Article
Closed access
JKJiri Kassa
Jiri Kassa
The cholinesterase-inhibiting organophosphorus compounds referred to as nerve agents (soman, sarin, tabun, GF agent, and VX) are particularly toxic and are considered to be among the most dangerous...

1 December 2003 in Journal of Enzyme Inhibition and Medicinal Chemistry
Verified
Journal Article
Open access
Kamil KucaKamil Kuca
Kamil Kuca
JKJiri Kassa
Jiri Kassa
The efficacy of a new bispyridinium oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, called K048, and currently used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. The new oxime K048 was found to be a more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than pralidoxime (in the case of VX, tabun and cyclosarin), obidoxime (cyclosarin and tabun) and HI-6 (tabun) but it did not reach the efficacy of currently used oximes for the reactivation of acetylcholinesterase inhibited by sarin. Thus, the oxime K048 seems to be a relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, it could be useful for the treatment of a nerve agent-exposed population if information about detection of the type of nerve agent is not available.



1 April 2001 in Basic & Clinical Pharmacology & Toxicology
Verified
Journal Article
Closed access
JKJiri Kassa
Jiri Kassa
MPMiroslav Pecka
Miroslav Pecka
MTMilos Tichy
Milos Tichy
JBJiri Bajgar
Jiri Bajgar
MKMarie Koupilova
Marie Koupilova
ZKZuzana Krocova
Zuzana Krocova