Venous thromboembolism (VTE), which comprises deep vein thrombosis (DVT) and pulmonary embolism (PE), ranks among the leading causes of preventable mortality and morbidity, with 5% to 10% of hospital deaths attributed to PE.
1,2 The annual economic burden of VTE in the United States is estimated at $1.5 billion.
3 Major risk factors for VTE include cancer, surgery, advanced age, and trauma.
4 Patients with cancer undergoing surgery represent a special population at increased risk of VTE, the incidence of which is estimated at 1.5% to 2.1%.
5-8 Moreover, previous investigators have shown that patients undergoing oncologic procedures are at a 2- to 3-fold higher risk of fatal PE relative to their counterparts without cancer.
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