Many neurodegenerative disorders are characterized by the abnormal aggregation of misfolded proteins that form amyloid deposits which possess prion-like behavior such as self-replication, intercellular transmission, and consequent induction of native forms of the same protein in surrounding cells. The distribution of the accumulated proteins and their correlated toxicity seem to be involved in the progression of nervous system degeneration. Molecular chaperones are known to maintain proteostasis, contribute to protein refolding to protect their function, and eliminate fatally misfolded proteins, prohibiting harmful effects. However, chaperone network efficiency declines during aging, prompting the onset and the development of neurological disorders. Extracellular vesicles (EVs) are tiny membranous structures produced by a wide range of cells under physiological and pathological conditions, suggesting their significant role in fundamental processes particularly in cellular communication. They modulate the behavior of nearby and distant cells through their biological cargo. In the pathological context, EVs transport disease-causing entities, including prions, α-syn, and tau, helping to spread damage to non-affected areas and accelerating the progression of neurodegeneration. However, EVs are considered effective for delivering therapeutic factors to the nervous system, since they are capable of crossing the blood–brain barrier (BBB) and are involved in the transportation of a variety of cellular entities. Here, we review the neurodegeneration process caused mainly by the inefficiency of chaperone systems as well as EV performance in neuropathies, their potential as diagnostic biomarkers and a promising EV-based therapeutic approach.

In recent years, alternative uses of art within medical education have been explored and extended. We report here a method of art-based assignments in anatomy and histology, which we have incorporated into the head and neck course as a means of enlivening didactic lectures. One hundred and two first-year medical students at the Alborz University of Medical Sciences participated in a 15-week educational intervention, in which an art-based assignment method was employed. The learning module focuses on the human anatomy and histology of head and neck. In each session, after the teacher's lecture and practical work, students were given an assignment based on the topics of that session and based on the drawing. The learning outcome was evaluated twice, 1 week and 4 weeks after the course. Student's feedbacks were collected via an anonymous questionnaire at the end of the module. The data were analyzed by using the SPSS 20 software by paired and independent t-tests and the normality of data was evaluated by the Kolmogorov–Smirnov test. Most of students (90%) had rated the new format as very informative. Exam scores were significantly higher at 4 weeks tests (P ≤ 0.05) and data showed significant difference in long-term retention of knowledge. The use of this module by medical students during their head and neck course improves their confidence through drawing. Teacher's feedback provides a step-wise approach that simplifies the learning of anatomy and histology. The strategy has appeal for visual, auditory, read/write, and kinesthetic learners.

According to anatomical reference books, the celiac trunk (CT) is divided into three terminal branches, namely the common artery (SA). However, variations in the number and location of the CT branches are possible. The body of a 40-year-old deceased male was used for anatomization in the Anatomical Hall of Alborz University of Medical Sciences (Karaj, Iran). During the dissection, variations in the branching pattern of the CT, such as the orientation of the main celiac branches, the origin of the inferior phrenic artery, and the aberrant supplementary artery to supply the liver were observed. Furthermore, a variation in the location of the kidneys and renal arteries was observed. In addition to CHA, LGA, and SA, two additional branching patterns, namely the left inferior phrenic artery (LIPA), and right accessory hepatic artery (RAHA) were noticed. This variation is rarely observed in human anatomy. Therefore, awareness of the arterial anatomy and possible variations is essential during surgeries (e.g., biliary tract surgery, liver transplant) and radiological procedures. To the best of our knowledge, such variations in the branching pattern of the CT have not been reported or described in anatomical reference books. Hence, the present study aimed to highlight the existence of these variations to assist surgeons, radiologists, and anatomists.

Objective: There is no published literature about the types of head and face shapes in the Alborz newborns. Therefore, we designed this study to report these important regional data. Methods: Head length, head width, face length, face width, prosopic and cephalic indices were made on 150 newborns (75 males and 75 females) with a view to establish the criterion of cephalometry for this age group in Iran. A special emphasis was given to delivery mode in this study. Results: There was no significant difference in cephalic and prosopic indices between two groups (female: P = 0.46; male: P = 0.43). Brachycephalic type was dominant and dolicocephalic type was rare in male and female neonates. There was no significant difference in head shape between two groups. Hypereuriprosopic and hyperleptoprosopic were dominant and rare types, respectively, in newborns without significant difference between two groups. Conclusion: The head and face indices in the newborn infants born by cesarean section were not significantly different from vaginal delivery group. However, the role of nutrition and climate could not be ruled out.