The most prevalent type of gynecological malignancy globally is cervical cancer (CC). Complicated by tumor resistance and metastasis, it remains the leading cause of cancer deaths in women in South Africa. Early CC is managed by hysterectomy, chemotherapy, radiation, and more recently, immunotherapy. Although these treatments provide clinical benefits, many patients experience adverse effects and secondary CC spread. To minimize this, novel and innovative treatment methods need to be investigated. Photodynamic therapy (PDT) is an advantageous treatment modality that is non-invasive, with limited side effects. The Cannabis sativa L. plant isolate, cannabidiol (CBD), has anti-cancer effects, which inhibit tumor growth and spread. This study investigated the cytotoxic combinative effect of PDT and CBD on CC HeLa cells. The effects were assessed by exposing in vitro HeLa CC-cultured cells to varying doses of ZnPcS₄ photosensitizer (PS) PDT and CBD, with a fluency of 10 J/cm² and 673 nm irradiation. HeLa CC cells, which received the predetermined lowest dose concentrations (ICD₅₀) of 0.125 µM ZnPcS₄ PS plus 0.5 µM CBD to yield 50% cytotoxicity post-laser irradiation, reported highly significant and advantageous forms of cell death. Flow cytometry cell death pathway quantitative analysis showed that only 13% of HeLa cells were found to be viable, 7% were in early apoptosis and 64% were in late favorable forms of apoptotic cell death, with a minor 16% of necrosis post-PDT. Findings suggest that this combined treatment approach can possibly induce primary cellular destruction, as well as limit CC metastatic spread, and so warrants further investigation.

Attention deficit hyperactivity disorder (ADHD) is an increasingly prevalent behavioural disorder characterised by inattention, impulsivity and hyperactivity. Valeriana officinalis is a botanical medicine that has been found to be beneficial in the treatment of disorders characterised by restlessness. To date, no research has been conducted on homeopathic preparations of Valeriana officinalis for this condition. The aim of this three-week, double-blind, placebo-controlled pilot study was to determine the efficacy of homeopathic Valeriana officinalis mother tincture (MT) and 3X potency on ADHD. Thirty children between the ages of five and 11 years, pre-diagnosed with ADHD, were recruited. Valeriana officinalis MT (n = 10), 3X (n = 10) or placebo (n = 10) were administered orally three times a day for two weeks. Efficacy was assessed by the Barkley and DuPaul teacher rating scale, the children’s checking task and the parent symptom questionnaire scores on day 1 (prior to treatment), at the end of weeks two and three (with treatment), and then after the third week following no treatment. A statistically significant improvement was found in the participants’ behaviour in the MT and 3X groups, with particular reference to sustained attention, anxiety and impulsivity and/or hyperactivity. Preliminary findings suggested that Valeriana officinalis MT and 3X may have applications in the management of ADHD.Aandagsgebrek-hiperaktiwiteitsindroom (AGHS) is toenemend ’n algemene gedragsongesteldheid, wat gekenmerk word deur onoplettendheid, impulsiwiteit en hiperaktiwiteit. Daar is vasgestel dat Valeriana officinalis ’n plantaardige medisyne is wat voordelig kan wees in die behandeling van ongesteldhede wat gekenmerk word deur rusteloosheid. Tot op hede is geen navorsing uitgevoer op die gebruik van homeopatiese preparate van Valeriana officinalis vir hierdie ongesteldheid nie. Die doel van hierdie drieweeklange, dubbelblinde, troosmedisyne-gekontroleerde loodsstudie was om die effektiwiteit van homeopatiese Valeriana officinalis Moertinktuur (MT) en 3X sterkte vir die behandeling van AGHS te bepaal. Dertig kinders tussen die ouderdomme van 5 en 11 jaar, wat vantevore gediagnoseer is met OGHO, is gewerf. Valeriana officinalis MT (n = 10), 3X (n = 10) of troosmedisyne (n = 10) is mondeliks drie keer per dag vir twee weke toegedien. Effektiwiteit is gemeet op dag 1 (voor behandeling), aan die einde van weke twee en drie (tydens behandeling), en na die derde week sonder behandeling deur middel van tellings wat behaal is op die Barkley and DuPaul teacher rating scale, die children’s checking task en die parent symptom questionnaire. ’n Statisties beduidende verbetering is gevind in die gedrag van die deelnemers in die MT en 3X groepe, in die besonder met betrekking tot volgehoue oplettendheid, angstigheid en impulsiwiteit en/of hiperaktiwiteit. Voorlopige bevindinge dui daarop dat Valeriana officinalis MT en 3X moontlik gebruik kan word in die behandeling van AGHS.

Background: The increased popularity of complementary medicine has created the need for patients to receive accurate information from nurses who are front-line healthcare providers. Studies have demonstrated that patients are more likely to discuss other medication and therapy use with nurses, rather than with general practitioners or other health professionals. It is, therefore, important to determine nurses' knowledge and attitudes towards complementary medicine. Aim: The aim of this study was to determine nursing students' knowledge and attitudes toward the use of complementary medicine. Setting: The study was conducted with Baccalaureus Curationis (nursing) students registered at a large public university in Gauteng, South Africa. Methods: This research utilised a quantitative approach with a prospective, descriptive survey design. A convenience sample comprising registered Baccalaureus Curationis nursing students (n = 202) was utilized. Participants completed a 34-item, paper-and-pencil questionnaire to determine their knowledge, personal use and attitude toward complementary medicine modalities. Results: Questionnaires were completed by 126 nursing students with 119 questionnaires included for analysis. Despite a reported lack of knowledge regarding complementary medicine and limited personal use, participants had an overall positive attitude towards complementary medicine. Almost half of the participants reported enquiring about its use in history taking and were willing to refer patients to a complementary medicine practitioner. Conclusion: A positive attitude towards complementary medicine modalities might suggest a willingness from students to improve their knowledge of the various modalities and to refer to a complementary medicine practitioner when indicated.

Student engagement plays an important role in promoting student success at higher education institutions. It is of profound significance to improve student engagement through the utilisation of effective pedagogical approaches, such as game-based learning. However, there is a lack of study in the South African context focusing on game-based learning at higher education institutions. This study aimed to explore students’ views and experiences on game-based learning at an identified university in South Africa. The constructivism learning theory was anchored in this study as a theoretical lens. In this study, the authors adopted a qualitative single case study design within an interpretivist paradigm. A purposive sampling technique was followed to recruit participants from a public university in South Africa since it is the only university that provides acupuncture programmes in this country. Six participants were recruited for this study. The authors utilised thematic analysis to analyse the data. The findings of this study revealed that participants shared positive views and attitudes toward game-based learning. They believed that game-based learning significantly motivated them in the learning process. Furthermore, game-based learning also reduced their stress in learning compared to the learning in normal classrooms. They reported that game-based learning not only improved their engagement in learning but also enhanced their knowledge and skills. This study also highlighted that game-based learning should be well-planned to avoid demotivating students. It can be concluded that game-based learning is an effective approach to improve student engagement. Further studies should be conducted with diverse research approaches at different higher education institutions.

Interprofessional education (IPE) is a practical pedagogical approach to strengthening teaching and learning in higher education to improve students' competencies. These competencies include an enhanced understanding of content knowledge and skills from different professions. To ensure quality teaching and learning, it is envisaged that IPE will strengthen and advance the knowledge and skills of students. The COVID-19 pandemic offered the opportunity to adopt multiple approaches to support students in acquiring the knowledge, skills, values and attitudes towards the programme through the support of interprofessional educators and resources. However, there is a lack of research to explore students' experiences and views on IPE in an acupuncture programme within the South African context, particularly with technologies. This study was anchored in the Technological, Pedagogical, Content Knowledge model as a theoretical lens to explore students' experiences of the IPE using technologies. The authors employed an interpretivist paradigm within a qualitative case study design. They used purposive sampling as a technique since the participants in this study were acupuncture students at a South African university. The researchers interviewed six (6)undergraduate students for this study. The findings revealed that students showed positive attitudes towards IPE. They believed the IPE would improve their competencies in clinical practice. Results also suggested that specific programmes should allocate sufficient time for IPE. Institutions should provide professional training to academics since IPE require more comprehensive content knowledge and pedagogical approaches. To promote effective teaching and learning, IPE should be the norm at universities. Universities should provide relevant support for the appropriate implementation of IPE from policy and resource perspectives.

Background: The quality of homeopathic research studies is controversially discussed. In order to improve, the overall assessment of homeopathic studies and subsequently facilitate evidence-based clinical decision-making, we aimed to combine methodological tools for scientific rigor with tools for external and model validity into one global tool. Method: Against the background of previous literature and the results of a preparatory survey, a first draft of a potential overarching tool was presented to an expert panel. Then, Delphi feedback rounds were conducted to elicit responses on the feasibility. The resulting preliminary tool was pilot-tested by five research experts on five randomly selected studies. After further optimization, another five studies were assessed by the same experts and another three experts tested the second version. The ratings were tested for interrater-reliability using Gwet’s AC2. Results: The appraisal tool comprises four domains. These are (1) the assessment of risk-of-bias using the Cochrane Tool, (2) the studies’ credibility including the CONSORT statement and its extension on homeopathy, (3) the study interventions’ coherence with homeopathic textbooks and previous research, and (4) the studies’ clinical relevance. Each domain is assessed using a point system, which is then added up to an overall score. The instrument was evaluated as useful and “easy to apply” by the raters. The interrater reliability was 0.81 (95% CI 0.75–0.88) for five raters, and 0.64 (95% CI 0.49–0.79) for additional three raters in round 2, signifying good to moderate interrater reliability. Conclusion: We have developed an applicable and reliable assessment tool for homeopathic intervention studies. Using it in systematic reviews and meta-analyses will increase their scientific value.