Dr. Samuele Tardito obtained his PhD in Clinical and Experimental Immunology in the laboratory of Prof. G. Filaci at the University of Genoa. Over the following years, he has gained experience in cancer and autoimmune T-cell biology (both in human and in mouse diseases). Concurrent with his post-doc research, he expanded his T-cell biology research experience in the psychiatric clinical diseases (such as bipolar disorder). He also deepened his knowledge on autoimmune disease immunotherapy in the Laboratory of Prof. M. Cutolo at the University of Genoa, with a scientific project on the potential of CTLA4-Ig fusion protein to induce an in vitro phenotypical shift of macrophages (from an inflammatory to anti-inflammatory state). Currently, he is working under the supervision of Professor A. Poggi (IRCCS Polyclinic San Martino Hospital in Genoa). His scientific research is now focused on generating organoids derived from colorectal and breast cancer tissue, with the aim of inducing the activation, expansion, and cytotoxic function of Vδ2T lymphocytes. This scientific training has focused his passion in generating organoids from patient’s tumors or from hiPSCs, to study the tumor micro-environment and its modulation of T-cell therapy. Moreover, to understand the mechanisms at the basis of tumor growth, Dr. Tardito is implementing experiments that will allow for the establishment of “assembloid”, a tissue generated from the fusion of two different human tissue-derived organoids.