Marine fog represents a critical but variable water resource in hyperarid coastal regions, yet its chemical variability at the event scale and meteorological controls remain poorly characterized. This study provides an event-based characterization of fog water chemistry at Alto Patache (~20°S), Atacama Desert, Chile, based on 28 fog events sampled between 2022 and 2024 using a Caltech Active Strand Cloudwater Collector (CASCC) with meteorological monitoring. Seven chemical parameters were measured in situ (alkalinity, hardness, pH, phosphate, ammonium, nitrite, and nitrate), and k-means clustering identified three chemically distinct regimes: dilute (Cluster 0, n = 19), enriched (Cluster 1, n = 6), and buffered (Cluster 2, n = 3), validated by permutation-based analysis (PERMANOVA, p < 0.001). Fog events with higher water yields are associated with better water quality: fog water volume showed the strongest relationship with solute concentration, consistent with a dilution mechanism, with high-yield events showing substantially lower ionic concentrations. Event duration and wind speed exhibited secondary complementary patterns, while wind direction had no clear relationship with fog chemistry. These findings indicate that fog water quality is closely linked to event-scale hydrological processes, with direct implications for fog harvesting management, water quality assessment, and understanding biogeochemical subsidies in fog-dependent ecosystems.