Exploring the landscape ecological security pattern and its driving mechanisms in key economic zones is of great significance for preventing and resolving landscape ecological risks and promoting regional sustainable development. This study quantitatively analyzed the land use change characteristics in the Huaihe River Eco-economic Belt from 1980 to 2020 using the land use transfer matrix and land use intensity index. Further, the evolution of ecological risks and their driving mechanisms were investigated using the landscape pattern index and hierarchical partitioning analysis. The results show that (1) in terms of absolute area, dryland, grassland, and paddy land decreased by 7075 km², 2708 km², and 1874 km², respectively, while urban–rural land and water area increased by 10,538 km² and 1336 km², respectively. In terms of change intensity, grassland, water area, urban–rural land, and unused land exhibited the most dramatic change, whereas forest land, paddy land, and dryland exhibited weaker change. (2) The conversions in the study area were primarily between dryland, paddy land, and urban–rural land. Paddy land and dryland tended to convert to urban–rural land, which is further likely to be transformed into dryland and unused land when converted. (3) The study area mainly presented medium to low ecological risk. Overall, the ecological risk remained stable throughout the study period. Nevertheless, Jining, Zaozhuang, and Bengbu show high ecological risks in the construction of the economic zone. (4) Forest land explained 40% of the variance in landscape risk, whereas urban–rural land and dryland each explained 20% of the variance. An increase in the proportion of urban–rural land and dryland will increase landscape ecological risk. However, after urban–rural land exceeds 15%, the ecological security risk does not increase significantly with increasing proportion of urban–rural land.

The interactions of water, energy, and food, which are essential resources for human survival, livelihoods, production, and development, constitute a water–energy–food (WEF) nexus. Applying symbiosis theory, the economic, social, and natural factors were considered at the same time in the WEF system, and we conducted a micro-level investigation focusing on the stability, coordination, and sustainability of the symbiotic units (water, energy, and food), and external environment of the WEF system in 36 prefecture-level cities across three northeastern provinces of China. Finally, we analyzed the synergistic safety and coupling coordination degree of the WEF system by the combination of stability, coordination, and sustainability, attending to the coordination relationship and influences of the external environment. The results indicated that the synergistic safety of the WEF system in three northeastern provinces need to equally pay attention to the stability, coordination, and sustainability of the WEF system, since their weights were 0.32, 0.36 and 0.32, respectively. During 2010–2016, the synergistic safety indexes of the WEF system ranged between 0.40 and 0.60, which was a state of boundary safety. In the current study, the coupling coordination degree of the WEF system fluctuated around a value of 0.6, maintaining a primary coordination level; while in the future of 2021–2026, it will decline to 0.57–0.60, dropping to a weak coordinated level. The conclusion could provide effective information for decision-makers to take suitable measures for the security development of a WEF system.