Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) evading immune destruction, (ix) genome instability and mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, and (xiv) senescent cells. These hallmarks are also associated with the development of breast cancer, which represents the most prevalent tumor type in the world. The present narrative review aims to describe, for the first time, the effects of physical activity/exercise on these hallmarks. In summary, an active lifestyle, and particularly regular physical exercise, provides beneficial effects on all major hallmarks associated with breast cancer, and might therefore help to counteract the progression of the disease or its associated burden.

(1) Background: The use of wearable cuffless devices has emerged as an out-of-office blood pressure (BP) monitor device to improve the management of hypertension. We aimed to validate a new, low-cost smartwatch for the measurement of BP and, secondarily, to assess its reliability for the measurement of blood oxygen saturation (SpO₂) and heart rate. (2) Methods: We compared 1000 pairs of measurements (n = 100) acquired by a smartwatch (KC08) with those measured by a reference device. (3) Results: A total of 100 participants (41 ± 18 years) completed the measurements. The values for the systolic and diastolic BP, heart rate and SpO₂ measured with the Smartwatch KC08 and the reference devices differed significantly (p < 0.05). In addition, the Smartwatch KC08 showed a low variability and poor reliability for all the assessed outcomes except for the heart rate. Moreover, no significant heteroscedasticity was observed for the heart rate measured by the Smartwatch KC08 and the reference sphygmomanometer. (4) Conclusions: The main findings of the present study suggest that the Smartwatch KC08 is not yet suitable for daily clinical practice, although it showed low intra-subject variability and reliability for the resting heart rate.