Major hurricanes are a critical hazard for North and Central America. The present study investigated the trends of occurrence, affectation, and intensity of major hurricanes in the North Atlantic and Northeast Pacific Oceans using GIS applications to the IBTrACS database. The study period ranged from 1970 to 2021. Tropical cyclones were sampled using a grid composed of 3.5° hexagonal cells; in addition, trends were obtained to assess the effect of long-term variability from natural phenomena and climate change. Critical factors influencing these trends at the oceanic scale and for each hexagon were determined using multivariate and multiscale analysis by the application of stepwise analysis and the related ANOVA. The integrated variables related to atmospheric and oceanographic oscillations and patterns, i.e., spatial variables resampled with the same analysis unit and climate indices. Our results indicated marked spatial areas with significant trends in occurrence and intensity. Additionally, there was evidence of linear changes in the number of major hurricanes and an increase in the maximum annual speed of +1.61 m s⁻¹ in the North Atlantic basin and +1.75 m·s⁻¹ in the Northeast Pacific, reported for a 10-year period. In terms of occurrence, there were increases of 19% and 5%, respectively, which may be related to ocean warming and natural variability associated with oceanic and atmospheric circulation.