Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory response in various ways. On the other hand, high-density lipoproteins (HDL) exhibit substantial anti-inflammatory and antioxidant actions. Consequently, novel inflammatory blood biomarkers have emerged, such as neutrophil to HDL ratio (NHR) and monocyte to HDL ratio (MHR). Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 30 November 2022 dealing with NHR and MHR as biomarkers for IS prognosis. Only full-text articles published in the English language were included. Thirteen articles have been traced and are included in the present review. Our findings highlight the utility of NHR and MHR as novel stroke prognostic biomarkers, the widespread application, and the calculation of which, along with their inexpensive cost, make their clinical application extremely promising.

Stroke remains a predominant cause of mortality and disability worldwide. The endeavor to diagnose stroke through biomechanical time-series data coupled with Artificial Intelligence (AI) poses a formidable challenge, especially amidst constrained participant numbers. The challenge escalates when dealing with small datasets, a common scenario in preliminary medical research. While recent advances have ushered in few-shot learning algorithms adept at handling sparse data, this paper pioneers a distinctive methodology involving a visualization-centric approach to navigating the small-data challenge in diagnosing stroke survivors based on gait-analysis-derived biomechanical data. Employing Siamese neural networks (SNNs), our method transforms a biomechanical time series into visually intuitive images, facilitating a unique analytical lens. The kinematic data encapsulated comprise a spectrum of gait metrics, including movements of the ankle, knee, hip, and center of mass in three dimensions for both paretic and non-paretic legs. Following the visual transformation, the SNN serves as a potent feature extractor, mapping the data into a high-dimensional feature space conducive to classification. The extracted features are subsequently fed into various machine learning (ML) models like support vector machines (SVMs), Random Forest (RF), or neural networks (NN) for classification. In pursuit of heightened interpretability, a cornerstone in medical AI applications, we employ the Grad-CAM (Class Activation Map) tool to visually highlight the critical regions influencing the model’s decision. Our methodology, though exploratory, showcases a promising avenue for leveraging visualized biomechanical data in stroke diagnosis, achieving a perfect classification rate in our preliminary dataset. The visual inspection of generated images elucidates a clear separation of classes (100%), underscoring the potential of this visualization-driven approach in the realm of small data. This proof-of-concept study accentuates the novelty of visual data transformation in enhancing both interpretability and performance in stroke diagnosis using limited data, laying a robust foundation for future research in larger-scale evaluations.

Background/Objectives: Falls among the older adult population represent a significant public health concern, often leading to diminished quality of life and serious injuries that escalate healthcare costs, and they may even prove fatal. Accurate fall risk prediction is therefore crucial for implementing timely preventive measures. However, to date, there is no definitive metric to identify individuals with high risk of experiencing a fall. To address this, the present study proposes a novel approach that transforms biomechanical time-series data, derived from gait analysis, into visual representations to facilitate the application of deep learning (DL) methods for fall risk assessment. Methods: By leveraging convolutional neural networks (CNNs) and Siamese neural networks (SNNs), the proposed framework effectively addresses the challenges of limited datasets and delivers robust predictive capabilities. Results: Through the extraction of distinctive gait-related features and the generation of class-discriminative activation maps using Grad-CAM, the random forest (RF) machine learning (ML) model not only achieves commendable accuracy (83.29%) but also enhances explainability. Conclusions: Ultimately, this study underscores the potential of advanced computational tools and machine learning algorithms to improve fall risk prediction, reduce healthcare burdens, and promote greater independence and well-being among the older adults.