The transmission rate of many acute infectious diseases varies significantly in time, but the underlying mechanisms are usually uncertain. They may include seasonal changes in the environment, contact rate, immune system response, etc. The transmission rate has been thought difficult to measure directly. We present a new algorithm to compute the time-dependent transmission rate directly from prevalence data, which makes no assumptions about the number of susceptible or vital rates. The algorithm follows our complete and explicit solution of a mathematical inverse problem for SIR-type transmission models. We prove that almost any infection profile can be perfectly fitted by an SIR model with variable transmission rate. This clearly shows a serious danger of overfitting such transmission models. We illustrate the algorithm with historic UK measles data and our observations support the common belief that measles transmission was predominantly driven by school contacts.
1 February 2001 in Ergodic Theory and Dynamical Systems
We present a powerful approach to computing the Hausdorff dimension of certain conformally self-similar sets. We illustrate this method for the dimension \mathop{\rm dim}\nolimits_H(E_2) of the set E_2, consisting of those real numbers whose continued fraction expansions contain only the digits 1 or 2. A very striking feature of this method is that the successive approximations converge to \mathop{\rm dim}\nolimits_H(E_2) at a super-exponential rate
We establish stable ergodicity of diffeomorphisms with partially hyperbolic attractors whose Lyapunov exponents along the central direction are all negative with respect to invariant SRB-measures.