Purpose: Alopecia Areata (AA) is a complex autoimmune condition characterized by long-term inflammatory non-scarring patches of hair loss on the face, scalp, and body. Its development involves a combination of genetic, immunological, and environmental factors, making it challenging to understand and treat. This study aims to assess the awareness, beliefs, and psychological impact of patients Patients and Methods: This cross-sectional study was conducted in Eastern and Central provinces of Saudi Arabia and utilized online questionnaires to evaluate knowledge, beliefs, and psychological effects of patients with Alopecia Areata. These questionnaires were distributed using social media platforms. Results: This study enrolled 248 patients with Alopecia Areata (AA), of whom 38.7% were aged 31-40 years and 55.2% were males. The majority were Saudis (98.4%), married (54%), and residing in the Central Region (60.1%). Nearly half (48.8%) were employed in non-medical fields, and 30.6% were vocational school graduates. Healthcare providers were the main source of AA information (52.8%), with most patients aware of AA's seriousness, curability, and quality of life impact, though many had low knowledge and experienced negative psychological effects such as shyness, anxiety, and depression. Conclusion: Despite low self-rated knowledge, most patients recognized AA as serious and requiring treatment. Psychological wellbeing was heavily impacted by AA severity, quality of life, disease duration, and treatment efficacy. Although many patients showed improved AA status and good medication compliance, adverse psychological effects persisted, highlighting the need for larger studies to better understand and address these issues.

Purpose: Minimally invasive aesthetic procedures are widely popular among the youth. Despite their prevalence, there is a significant gap in the research concerning the relationship between these procedures and psychological wellbeing, as well as an insufficient exploration of the barriers and motivators influencing their adoption, this study aims to address these gaps. Methods: This cross-sectional study has utilized a secure online survey directed at Saudi university students as the target population. The survey was consisting of 18-item electronic questionnaire including of 4 parts (demographical data, history of psychological illness and screening of current psychological wellbeing using WHO-5 well-being tool, history of doing cosmetic procedure, or willingness to do in the future, barriers and motivators to do cosmetic procedures), and it was distributed across multiple social media platforms. Results: A total of 8443 college students completed the study questionnaire. Exactly 1096 (13%) of the students underwent a cosmetic procedure. The most reported procedures were laser hair removal (9.1%), filler (5.3%), skin boosters (2.8%), and Botulinum toxin A injections (Botox) (2.6%). The most ranked motivators were being painless, with no side effects (8.8 out of 10), followed by being free (8.0 out of 10) and enhancing self-confidence (7.4 out of 10). Conclusion: No significant difference recorded at the overall psychological well-being score between who underwent cosmetic procedures and who did not.

Mycosis fungoides (MF) is one of the primary cutaneous T-cell lymphomas and is considered to be the most common extranodal non-Hodgkin lymphomas. MF is characterized by different subtypes based on clinical presentation and immunophenotyping studies. We aimed to study the clinical patterns and treatment response in cases of MF among the patients attending a tertiary referral hospital in Saudi Arabia. A retrospective study, case record-based study was done to review all the patients diagnosed with MF from January 2011 to May 2016. All cases with histopathological confirmation and immunophenotyping were included in the study. Treatment follow-up was reviewed for 9 months in all cases. Treatment response was graded based on a global physician assessment-complete response, good response, moderate response, and minimal or no response. Out of 34 cases of MF included in the study, 11 were hyperpigmented MF, 21 were hypopigmented MF, and there was one case each of poikilodermatous MF and pagetoid reticulosis. Of the total, fourteen (66.7%) of hypopigmented MF patients showed a complete response to phototherapy Narrowband UVB (NB-UVB) in combination with topical corticosteroids. Nine (81.8%) of hyperpigmented MF patients showed partial to the phototherapy NB-UVB in combination with the topical corticosteroid. Among the other types; one case of poikilodermatous MF (2.9%) showed a moderate response to phototherapy NB-UVB with topical corticosteroid and systemic acitretin. The most common type of MF seen in our study was the hypopigmented type, affecting a younger age group, and the same showed a good response to phototherapy NB-UVB combined with topical corticosteroids.

Background: Premature graying of the hair (PMGH), commonly referred to as canities, is a condition that has both genetic and environmental causes, all of which are not fully understood, and is typically accompanied by severe psychological distress. Studies are limited regarding PMGH, with no clear guidelines available. Methods: A cross-sectional study was conducted during the academic year 2023–2024 among medical students in a college in Saudi Arabia. Results: Out of 239 medical students surveyed (mean age of 22.9 ± 5.3 years; 54.4% female), the prevalence of premature graying of hair (PMGH) was 37.2%. PMGH was significantly associated with smoking (80% vs. 34.8%; p = 0.003), keto diet (72.7% vs. 35.5%; p = 0.013), hair coloring (51.2% vs. 34.3%; p = 0.042), and family history of PMGH (47.7% vs. 20%; p = 0.001). Although our study did not directly measure psychological stress, the findings suggest that stressful factors and lifestyle changes common among medical students may contribute to the development of premature graying of hair. Conclusions: This study demonstrates that early hair graying is caused by both genetic and modifiable factors, and its incidence and psychosocial effects might be lessened with increased awareness and early lifestyle changes.

BACKGROUND Artificial intelligence (AI) applications in dermatology show promising potential for diagnostic support and healthcare accessibility, yet successful implementation requires understanding public acceptance patterns. Limited research has examined attitudes toward AI specifically in dermatology within culturally diverse populations. This study assessed Saudi public attitudes toward AI in dermatology to inform implementation strategies for similar healthcare contexts. OBJECTIVE To evaluate knowledge, attitudes, and acceptance factors regarding AI applications in dermatology among Saudi adults and identify demographic and experiential predictors of AI adoption intentions. METHODS We conducted a cross-sectional online survey among Saudi adults aged 18 years and older from May 21 to June 5, 2025. The survey included 30 items divided into three sections: demographics (10 items), attitudes toward AI in dermatology (20 items on a 5-point Likert scale), and system priority ratings (6 items on a 5-point importance scale). We employed convenience and snowball sampling through social media platforms. For data analysis, we used descriptive statistics, one-way ANOVA for group comparisons, and binary logistic regression to identify predictors of high behavioral intention. We set the statistical significance at P < .05. RESULTS The study included 668 participants (61.1% female, 45.4% aged 18-24 years). Participants demonstrated high overall acceptance of AI in dermatology (mean score: 74.48 ± 10.20, Cronbach's α = 0.868). Strong preferences emerged for physician-supervised AI systems rather than autonomous implementations, with medical supervision receiving the highest endorsement (4.27 ± 0.87), followed by explainable AI decisions (4.12 ± 0.82) and physician authority during diagnostic disagreements (4.11 ± 0.86). While recognizing AI's potential benefits for healthcare access in remote areas (3.92 ± 0.94) and cost reduction (3.81 ± 0.86), participants expressed moderate enthusiasm for personal use (3.60 ± 0.97) and reservations about independent AI diagnosis (3.26 ± 0.97). System priorities emphasized privacy protection (56.4% rated as very important) and diagnostic accuracy (55.8%), followed by cultural compatibility (49.3%) and decision transparency (47.2%). Age significantly influenced acceptance (P = .009), with younger adults (18-24 years) showing the highest acceptance (75.96 ± 9.38). Technology interest demonstrated the strongest associations with both acceptance and perceived importance (P < .001). Healthcare professionals valued AI's importance more than general participants (P = .004) while maintaining similar acceptance levels. Gender, geographic region, education level, and dermatological experience showed no significant associations with acceptance patterns. CONCLUSIONS Saudi adults demonstrate predominantly positive yet nuanced attitudes toward dermatological AI, with strong preferences for collaborative physician-AI models over autonomous systems. Successful implementation requires prioritizing transparent, secure AI architectures with physician oversight, developing targeted educational initiatives across demographic groups, and ensuring cultural responsiveness in AI system design. These findings provide crucial baseline data for AI integration within Saudi Arabia's Vision 2030 healthcare objectives and offer insights relevant for culturally diverse healthcare contexts globally.

Spitz naevus (SN) are benign melanocytic lesions, which are classified into solitary, agminated, or disseminated forms. The most common form is solitary SN, typically occurring on the face and extremities of children. However, the disseminated SN is a rare presentation that can be either rapid eruptive or non-eruptive. The eruptive disseminated Spitz naevus (EDSN) often develops between the ages of 10 and 20 and affects nearly the whole-body surface, beginning in the trunk and/or extremities. Without prior reports from the population of Saudi Arabia, this eruptive SN has reportedly impacted native Alaskans (Americans), Koreans, Pakistanis, African Americans, and Hispanics. Eruptive disseminated SNs are rare, with only 27 cases having been reported in the literature. This article presents another case of EDSN.