The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and extracellular vesicles (EVs), require extensive reformulation to suit the requirements of PDD. LPs are artificial vesicles composed of lipid bilayers capable of encapsulating hydrophilic and hydrophobic substances, whereas EVs are natural vesicles secreted by cells. Additionally, novel LPs-EVs hybrid vesicles may confer the best of both. The preparation methods of EVs are distinguished from LPs since they rely mainly on extraction and purification, whereas the LPs are synthesized from their basic ingredients. Similarly, drug loading methods into/onto EVs are distinguished whereby they are cell- or non-cell-based, whereas LPs are loaded via passive or active approaches. This review discusses the progress in LPs and EVs as well as hybrid vesicles with a special focus on PDD. It also provides a perspective comparison between LPs and EVs from various aspects (composition, preparation/extraction, drug loading, and large-scale manufacturing) as well as the future prospects for inhaled therapeutics. In addition, it discusses the challenges that may be encountered in scaling up the production and presents our view regarding the clinical translation of the laboratory findings into commercial products.

The aim of this study was to determine the effect of eugenol on the integrity of the cell wall of Candida albicans. Minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and percentage inhibition of diameter growth (PIDG) of eugenol on C. albicans (ATCC 14053) were determined. The effect of eugenol on the growth profile was also evaluated. The release of cellular material and changes in cell permeability, including ultrastructural alterations to the morphology, were assessed using scanning electron microscopy, and surface disruption to the cell wall structure of C. albicans by atomic force microscopy. The MIC and MFC values of eugenol were found to be 1.0% v/v, while the PIDG was dose dependent. Eugenol influenced cell growth and was fungicidal towards C. albicans. Eugenol was also found to encourage cell leakage, causing the release of cellular material, and to increase cell permeability. The ultrastructure and cell surface morphology were also altered by the presence of eugenol. Thus, eugenol was found to disrupt the cell wall of C. albicans.

Cancer becomes a serious issue on society with increasing of their growth and proliferation, either in well economic developed countries or not. Recent years, oral cancer is one of the most threatening diseases impairing the quality of life of the patient. Scientists have emphasised on application of gene therapy for oral cancer by using nanoparticle as transportation vectors as a new alternative platform in order to overcome the limitations of conventional approaches. In modern medicine, nanotechnologies' application, such as nanoparticles-mediated gene delivery, is one of promising tool for therapeutic devices. The objective of this article is to present a brief review summarizes on the current progress of nanotechnology-based gene delivery treatment system targeted for oral cancer.

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.