In this study vocabulary development of a sample of 42 Italian children was evaluated through monthly administration of the Italian version of the CDI. Data collection started at 1;0–1;1 for 32 children and at 1;3–1;4 for the remaining subjects and continued until children's vocabulary reached 200 words. At fixed stages of vocabulary size (50, 100 and 200 words), individual differences in percentile scores and vocabulary composition were examined. Individual growth curves were analysed in order to verify the presence of a vocabulary spurt and the type of lexical items which contributed most to rapid acceleration in vocabulary growth.Stylistic differences in vocabulary composition were examined regarding the ‘referential–expressive’ distinction, controlling vocabulary size. Data have shown that general trends in vocabulary development are quite similar to those obtained for other languages using CDI adaptations. Moreover, all children in this sample eventually exhibited a vocabulary spurt, even if some can be defined as ‘late spurters’. The type of lexical items which are learned during the spurt depend on both infant vocabulary size and referential score. About 28% of infants in this sample were defined ‘referential’ when their vocabulary size was about 50 words, but the stylistic differences disappeared at the 100- and 200-word stages.Composition of vocabulary did not differ in relation to precocity in reaching different stages of vocabulary development. The only exception was that infants who reached the 50-word stage first also had a vocabulary with a lower proportion of function words.

Dilated cardiomyopathy (DCM) is a major complication and leading cause of death in Duchenne muscular dystrophy (DMD). DCM onset is variable, suggesting modifier effects of genetic or environmental factors. We aimed to determine if polymorphisms previously associated with age at loss of independent ambulation (LoA) in DMD (rs28357094 in the SPP1 promoter, rs10880 and the VTTT/IAAM haplotype in LTBP4) also modify DCM onset. A multicentric cohort of 178 DMD patients was genotyped by TaqMan assays. We performed a time-to-event analysis of DCM onset, with age as time variable, and finding of left ventricular ejection fraction < 50% and/or end diastolic volume > 70 mL/m² as event (confirmed by a previous normal exam < 12 months prior); DCM-free patients were censored at the age of last echocardiographic follow-up. Patients were followed up to an average age of 15.9 ± 6.7 years. Seventy-one/178 patients developed DCM, and median age at onset was 20.0 years. Glucocorticoid corticosteroid treatment (n = 88 untreated; n = 75 treated; n = 15 unknown) did not have a significant independent effect on DCM onset. Cardiological medications were not administered before DCM onset in this population. We observed trends towards a protective effect of the dominant G allele at SPP1 rs28357094 and recessive T allele at LTBP4 rs10880, which was statistically significant in steroid-treated patients for LTBP4 rs10880 (< 50% T/T patients developing DCM during follow-up [n = 13]; median DCM onset 17.6 years for C/C-C/T, log-rank p = 0.027). We report a putative protective effect of DMD genetic modifiers on the development of cardiac complications, that might aid in risk stratification if confirmed in independent cohorts.

The nature of near-death experiences (NDEs) is largely unknown but recent evidence suggests the intriguing possibility that NDEs may refer to actually “perceived”, and stored, experiences (although not necessarily in relation to the external physical world). We adopted an integrated approach involving a hypnosis-based clinical protocol to improve recall and decrease memory inaccuracy together with Electroencephalography (EEG) recording in order to investigate the characteristics of NDE memories and their neural markers compared to memories of both real and imagined events. We included 10 participants with NDEs, defined by the Greyson NDE scale, and 10 control subjects without NDE. Memories were assessed using the Memory Characteristics Questionnaire.Our hypnosis-based protocol increased the amount of details in the recall of all kind of memories considered (NDE, real, and imagined events). Findings showed that NDE memories were similar to real memories in terms of detail richness, self-referential, and emotional information. Moreover, NDE memories were significantly different from memories of imagined events. The pattern of EEG results indicated that real memories recall was positively associated with two memory-related frequency bands, i.e., high alpha and gamma. NDE memories were linked with theta band, a well-known marker of episodic memory. The recall of NDE memories was also related to delta band, which indexes processes such as the recollection of the past, as well as trance states, hallucinations, and other related portals to transpersonal experience. It is notable that the EEG pattern of correlations for NDE memories recall differed from the pattern for memories of imagined events. In conclusion, our findings suggest that, at a phenomenological level, NDE memories cannot be considered equivalent to imagined memories, and at a neural level, NDE memories are stored as episodic memories of events experienced in a peculiar state of consciousness.

This study investigated the somatic underpinning of empathy using an interpersonal physiology approach. Thirty-nine dyads were formed by a “pseudo-patient” and a “listener” (a therapist, a psychologist, or a non-therapist). Dyadic physiological concordance in electrodermal responses and listeners' empathy were evaluated during simulations of clinical sessions. A significant positive correlation between empathy as perceived by pseudo-patients and physiological concordance was found, providing empirical evidence of a somatic underpinning of empathy. Moreover, therapists showed higher levels of physiological concordance and empathy, confirming the importance of psychotherapy training in managing clinical interactions.

A crucial point for the understanding of the link between attachment and emotion regulation concerns the individual tendency in turning to others to alleviate distress. Most previous studies in this field have considered almost exclusively intra-personal forms of emotion regulation, neglecting the role of social interaction in emotion regulation processes. In the present study, instead, we focused on interpersonal emotion regulation. 630 adults were assessed for their attachment orientations, general difficulties in emotion regulation, and habitual intra-personal and interpersonal emotion regulation strategies. Results showed that the imbalance between the hyper-activation and deactivation of the attachment system, which characterize unsecure attachment, reflects a correspondent imbalance in the use of emotion regulation strategies, with an exaggerated dependence on other associated with attachment anxiety and pseudo-autonomy associated to attachment avoidance.