Raúl R Rodríguez-Berríos

Prof. Dr. Raúl R Rodríguez-Berríos

Chemistry, University of Puerto Rico at Río Piedras, San Juan, Puerto Rico, Puerto Rico
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Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 July 2023 in ACS ES&T Water
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Journal Article
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SPSiddappa Patil
Siddappa Patil
Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
DCDavid Chavez-Flores
David Chavez-Flores
DWDurgesh V. Wagle
Durgesh V. Wagle
Alejandro BugarinAlejandro Bugarin
Alejandro Bugarin

12 January 2023 in Antibiotics
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Journal Article
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SPSiddappa Patil
Siddappa Patil
ANAravind R Nesaragi
Aravind R Nesaragi
Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
SHSydney M. Hampton
Sydney M. Hampton
Alejandro BugarinAlejandro Bugarin
Alejandro Bugarin
Shivaputra PatilShivaputra Patil
Shivaputra Patil
Currently, in hospitals and community health centers, microbial infections are highly common diseases and are a leading cause of death worldwide. Antibiotics are generally used to fight microbial infections; however, because of the abuse of antibiotics, microbes have become increasingly more resistant to most of them. Therefore, medicinal chemists are constantly searching for new or improved alternatives to combat microbial infections. Coumarin triazole derivatives displayed a variety of therapeutic applications, such as antimicrobial, antioxidant, and anticancer activities. This review summarizes the advances of coumarin triazole derivatives as potential antimicrobial agents covering articles published from 2006 to 2022.

1 February 2011 in Tetrahedron
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Journal Article
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Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
GTGerardo Torres
Gerardo Torres
JPJose Antonio Prieto
Jose Antonio Prieto

23 February 2009 in The Journal of Organic Chemistry
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Journal Article
Closed access
WTWildeliz Torres
Wildeliz Torres
Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
JPJose Antonio Prieto
Jose Antonio Prieto

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Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
SISteven Isbel
Steven Isbel
Alejandro BugarinAlejandro Bugarin
Alejandro Bugarin
Polypropionate units are a common structural feature of many of the natural products in polyketides, some of which have shown a broad range of antimicrobial and therapeutic potential. Polypropionates are composed of a carbon skeleton with alternating methyl and hydroxy groups with a specific configuration. Different approaches have been developed for the synthesis of polypropionates and herein we include, for the first time, all of the epoxide-based methodologies that have been reported over the years by several research groups such as Kishi, Katsuki, Marashall, Miyashita, Prieto, Sarabia, Jung, McDonald, etc. Several syntheses of polypropionate fragments and natural products that employed epoxides as key intermediates have been described and summarized in this review. These synthetic approaches involve enatio- and diastereoselective synthesis of epoxides (epoxy-alcohols, epoxy-amides, and epoxy-esters) and their regioselective cleavage with carbon and/or hydride nucleophiles. In addition, we included a description of the isolation and biological activities of the polypropionates and related natural products that have been synthetized using epoxide-based approaches. In conclusion, the epoxide-based methodologies are a non-aldol alternative approach for the construction of polypropionate.

22 June 2023 in Antibiotics
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Journal Article
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Raúl R Rodríguez-BerríosRaúl R Rodríguez-Berríos
Raúl R Rodríguez-Berríos
ARAgnes M. Ríos-Delgado
Agnes M. Ríos-Delgado
APAmanda P. Perdomo-Lizardo
Amanda P. Perdomo-Lizardo
ACAndrés E. Cardona-Rivera
Andrés E. Cardona-Rivera
ÁVÁngel G. Vidal-Rosado
Ángel G. Vidal-Rosado
YOYermarie W. Ortiz-Colón
Yermarie W. Ortiz-Colón
The Caribbean region is a hotspot of biodiversity (i.e., algae, sponges, corals, mollusks, microorganisms, cyanobacteria, and dinoflagellates) that produces secondary metabolites such as polyketides and polypropionates. Polyketides are a diverse class of natural products synthesized by organisms through a biosynthetic pathway catalyzed by polyketide synthase (PKS). This group of compounds is subdivided into fatty acids, aromatics, and polypropionates such as macrolides, and linear and cyclic polyethers. Researchers have studied the Caribbean region to find natural products and focused on isolation, purification, structural characterization, synthesis, and conducting biological assays against parasites, cancer, fungi, and bacteria. These studies have been summarized in this review, including research from 1981 to 2020. This review includes about 90 compounds isolated in the Caribbean that meet the structural properties of polyketides. Out of 90 compounds presented, 73 have the absolute stereochemical configuration, and 82 have shown biological activity. We expect to motivate the researchers to continue exploring the Caribbean region’s marine environments to discover and investigate new polyketide and polypropionate natural products.