Integrating Artificial Intelligence (AI) in nursing practice is revolutionising healthcare by enhancing clinical decision-making and patient care. However, the adoption of AI by registered nurses, especially in varied healthcare settings such as Saudi Arabia, remains underexplored. Understanding the facilitators and barriers from the perspective of frontline nurses is crucial for successful AI implementation. This study aimed to explore registered nurses' perspectives on the facilitators and barriers to AI adoption in nursing practice in Saudi Arabia and to propose an extended Technology Acceptance Model for AI in Nursing (TAM-AIN). A qualitative study utilising focus group discussions was conducted with 48 registered nurses from four major healthcare facilities in Al-Kharj, Saudi Arabia. Thematic analysis, guided by the Technology Acceptance Model framework, was employed to analyse the data. Key facilitators of AI adoption included perceived benefits to patient care (85%), strong organisational support (70%), and comprehensive training programs (75%). Primary barriers involved technical challenges (60%), ethical concerns regarding patient privacy (55%), and fears of job displacement (45%). These findings led to the development of TAM-AIN, an extended model that incorporates additional constructs such as ethical alignment, organisational readiness, and perceived threats to professional autonomy. AI adoption in nursing practice requires a holistic approach that addresses technical, educational, ethical, and organisational challenges. The proposed TAM-AIN offers a comprehensive framework for optimising AI integration into nursing practice, emphasising the importance of nurse-centred implementation strategies. This model provides healthcare institutions and policymakers with a robust tool to facilitate successful AI adoption and enhance patient outcomes.

Background: Global population aging poses challenges for healthcare. Digital health technologies may benefit older adults through enhanced access, monitoring, and self-care. This systematic review evaluates the intersection of digital health interventions and healthy aging, focusing on adoption, efficacy, and user experience. Methods: PubMed, Embase, and Cochrane Library were systematically searched for studies on digital health technologies for adults aged 50+ years. Randomized controlled trials, observational studies, surveys, and qualitative studies were included. Outcomes were adoption rates, efficacy, and qualitative feedback. Study quality was assessed using standardized tools. Results: 15 studies were included. Adoption increased during COVID-19, but divisions persist. Barriers like technology challenges and distrust require addressing. Web-based programs and telerehabilitation demonstrated benefits for behaviors and balance. Users had positive attitudes but emphasized patient-centric, ethical design. Most efficacy data were preliminary; more rigorous trials are needed. Discussion: Digital health interventions show promise for supporting healthy aging, but thoughtful implementation strategies tailored to user needs and capacities are essential to realizing benefits equitably. More efficacy research and studies on real-world integration and ethics are warranted. Conclusions: Digital health has significant potential for promoting healthy aging through enhanced access, monitoring, and self-care. However, evidence-based, patient-centered solutions are imperative to maximize adoption, efficacy, and positive user experience for diverse older adult populations.

Workplace violence (WPV) remains a formidable concern among nurses worldwide, with up to 60% in Saudi Arabia reportedly experiencing some form of aggression. In tertiary care hospitals, robust hierarchies and cultural norms intensify underreporting, thwarting evidence-based prevention and obscuring vital data. This qualitative study investigated the perceived barriers to WPV reporting among nurses in tertiary care settings in the Aljouf region of Saudi Arabia, specifically addressing how organizational and cultural factors converge to discourage formal incident reporting. A qualitative descriptive design was employed, guided by Ajzen’s Theory of Planned Behavior and the Social Ecological Model. Thirty-six registered nurses, purposively sampled from three tertiary hospitals, participated in six semi-structured focus groups conducted in Arabic or English, depending on participant preference. Data were thematically analyzed in NVivo, with methodological rigor ensured through triangulation and inter-coder reliability. Three principal themes emerged: (1) Emotional and Psychological Barriers (78%), encompassing distress, anxiety, and fears of professional blame; (2) Organizational Ineffectiveness (65%), marked by convoluted reporting processes and perceived managerial indifference; and (3) Cultural and Hierarchical Influences (57%), reflecting deference to authority and normalization of violence. These themes illustrate how attitudes, subjective norms, and perceived behavioral control shaped by socio-cultural dynamics collectively contribute to persistent underreporting. Mitigating WPV underreporting in Saudi tertiary care hospitals requires streamlined, user-friendly reporting channels, leadership accountability, and holistic psychosocial support. Implementing interprofessional education aimed at dismantling hierarchical imbalances can foster a zero-tolerance ethos toward violence. Longitudinal and comparative research should further examine evolving reporting behaviors to refine context-specific, culturally attuned strategies for addressing WPV. Not applicable.

Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and peripheral resistance and is the most prevalent metabolic and endocrine disorder. However, the pathogenesis of DM also includes adipocyte insulin resistance, increased glucagon secretion, increased renal glomerular glucose absorption, and neurotransmitter dysfunction. Although there is a wide spectrum of therapeutics available for glycemic control, owing to the identification of various pathogenic determinants of DM, management of DM remains challenging and complex. Current therapeutic interventions against DM focus mostly on glycemic control without considering the other pathological determinants that eventually lead to treatment failure and the progression of DM. Furthermore, long-term use of these conventionally available anti-diabetic drugs leads to various side effects, henceforth development of novel drugs against DM remains an unending search strategy for researchers. Various studies conducted in various parts of the world have proposed that these novel therapeutic interventions target multiple and alternate pathogenic hotspots involved in DM. The current review article discusses novel therapeutic options that hold particular promise to support their safety and discuss the side effects resulting from their use so that these novel candidate drugs can be effectively fabricated into potential drugs for the treatment of DM.

Cyberbullying has emerged as a pervasive problem among high school students, with potentially severe consequences for their mental well-being. This study aimed to investigate the prevalence, risk factors, and associations of cyberbullying with stress and mental well-being among high school students in Zagazig, Egypt. A cross-sectional study was conducted among 562 high school students using a random sampling technique. The data were collected using a self-administered questionnaire that included the Cyberbullying Scale, Perceived Stress Scale (PSS-10), and General Health Questionnaire (GHQ-12). Descriptive statistics, independent samples t-tests, multiple regression, mediation, and logistic regression analyses were employed for data analysis. The prevalence of cyberbullying victimization was 38.3%, with 20.6% exposed to two or three cyberbullying behaviors and 4.1% exposed to four or more. Female students, those under 18 years old, those with lower educational achievement, and those with higher daily internet use were more likely to experience cyberbullying. Cyberbullied students reported significantly higher levels of perceived stress and poorer mental well-being compared to non-cyberbullied students. Perceived stress likely mediated the relationship between cyberbullying victimization and general psychological health. Cyberbullying is a significant problem among high school students in Zagazig, Egypt, with detrimental effects on their stress levels and mental well-being. Targeted interventions and prevention strategies are needed to address cyberbullying and promote the well-being of adolescents in the digital age.