The financial risk evaluation is critically vital for enterprises to identify the potential financial risks, provide decision basis for financial risk management, and prevent and reduce risk losses. In the case of considering financial risk assessment, the basic problems that arise are related to strong fuzziness, ambiguity and inaccuracy. q-rung orthopair fuzzy set (q-ROFS), portrayed by the degrees of membership and non-membership, is a more resultful tool to seize fuzziness. In this article, the novel q-rung orthopair fuzzy score function is given for dealing the comparison problem. Later, the and operations are explored and their interesting properties are discussed. Then, the objective weights are calculated by CRITIC (Criteria Importance Through Inter-criteria Correlation). Moreover, we present combined weights that reflects both subjective preference and objective preference. In addition, the q-rung orthopair fuzzy MCDM (multi-criteria decision making) algorithm based on CoCoSo (Combined Compromise Solution) is presented. Finally, the feasibility of algorithm is stated by a financial risk evaluation example with corresponding sensitivity analysis. The salient features of the proposed algorithm are that they have no counter-intuitive case and have a stronger capacity in differentiating the best alternative.

N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and the therapeutic functions of antibody-based drugs; however, low-abundance species are difficult to detect. Here we show a glycomic approach to detect these species on human IgGs using a specialized microfluidic chip. We discover 20 sulfated and 4 acetylated N-glycans on IgGs. Using multiple reaction monitoring method, we precisely quantify these previously undetected low-abundance, trace and even ultra-trace N-glycans. From 277 patients with rheumatoid arthritis (RA) and 141 healthy individuals, we also identify N-glycan biomarkers for the classification of both rheumatoid factor (RF)-positive and negative RA patients, as well as anti-citrullinated protein antibodies (ACPA)-positive and negative RA patients. This approach may identify N-glycosylation-associated biomarkers for other autoimmune and infectious diseases and lead to the exploration of promising glycoforms for antibody therapeutics.

Multi-omics data integration is a promising field combining various types of omics data, such as genomics, transcriptomics, and proteomics, to comprehensively understand the molecular mechanisms underlying life and disease. However, the inherent noise, heterogeneity, and high dimensionality of multi-omics data present challenges for existing methods to extract meaningful biological information without overfitting. This paper introduces a novel Multi-Omics Meta-learning Algorithm (MUMA) that employs self-adaptive sample weighting and interaction-based regularization for enhanced diagnostic performance and interpretability in multi-omics data analysis. Specifically, MUMA captures crucial biological processes across different omics layers by learning a flexible sample reweighting function adaptable to various noise scenarios. Additionally, MUMA incorporates an interaction-based regularization term, encouraging the model to learn from the relationships among different omics modalities. We evaluate MUMA using simulations and eighteen real datasets, demonstrating its superior performance compared to state-of-the-art methods in classifying biological samples (e.g., cancer subtypes) and selecting relevant biomarkers from noisy multi-omics data. As a powerful tool for multi-omics data integration, MUMA can assist researchers in achieving a deeper understanding of the biological systems involved. The source code for MUMA is available at https://github.com/bio-ai-source/MUMA .