Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.
1 June 2021 in Construction and Building Materials
The urgent need to replace fossil resource-based products is considerably increasing in the past few years, resulting in the search for more sustainable materials, with the aim of reducing the wastes from polymer pollution, solving economic and environmental issues. This is even more relevant in industrial fields, where toxic compounds are the basis of their polymeric formulations. Herein is reported the most relevant advances of epoxy resins (ERs) in the past decade, with great emphasis on the replacement of bisphenol A (BPA), leading to the production of renewable-based ERs with good properties. The synthesis of ERs based on renewable sources, such as vegetable oils, phenolic compounds, sugars and the outcome in the material’s structure is explored within this review. Emphasis is also given to the use of new biobased curing agents and biofillers to enhance the biocharacter of the ERs.