Continuous monitoring of human physiological signals is critical to managing personal healthcare by early detection of health disorders. Wearable and implantable devices are attracting growing attention as they show great potential for real‐time recording of physiological conditions and body motions. Conventional piezoelectric sensors have the advantage of potentially being self‐powered, but have limitations due to their intrinsic lack of stretchability. Herein, a kirigami approach to realize a novel stretchable strain sensor is introduced through a network of cut patterns in a piezoelectric thin film, exploiting the anisotropic and local bending that the patterns induce. The resulting pattern simultaneously enhances the electrical performance of the film and its stretchability while retaining the mechanical integrity of the underlying materials. The power output is enhanced from the mechano‐electric piezoelectric sensing effect by introducing an intersegment, through‐plane, electrode pattern. By additionally integrating wireless electronics, this sensing network could work in an entirely battery‐free mode. The kirigami stretchable piezoelectric sensor is demonstrated in cardiac monitoring and wearable body tracking applications. The integrated soft, stretchable, and biocompatible sensor demonstrates excellent in vitro and ex vivo performances and provides insights for the potential use in myriad biomedical and wearable health monitoring applications.

Rapid advances in sensing technologies are leading to the development of integrated wearable electronics for biomedical applications. Piezoelectric materials have great potential for implantable devices because of their self-powered sensing capacities. The soft and highly deformable surfaces of most tissues in the human body, however, restrict the wide use of piezoelectric materials, which feature low stretchability. Flexible piezoelectric polyvinylidene fluoride films that could conformably integrate with human bodies would have advantages in health monitoring. Here, a Kirigami technique with linear cut patterns has been employed to design a stretchable piezoelectric sensor with enhanced piezoelectricity. A parametric Finite Element Analysis study is first performed to investigate its mechanical behaviour, followed by experiments. An inter-segment electrode connection approach is proposed to further enhance the piezoelectric performance of the sensor. The voltage output shows superior performance with 2.6 times improvement compared to conventionally continuous electrodes. Dynamic tests with a range of frequencies and strains are performed to validate the sensor design. With its high performance in large strain measurements, the Kirigami-based sensing system shows promise in stretchable electronics for biomedical devices.