Many frequent and severe air pollution incidents have emerged across the vast parts of China recently. The identification of factors and mapping social vulnerability has become extremely necessary for environmental management and sustainable development. However, studies associating social vulnerability with air pollution remain sparse. With reference to research achievements of social vulnerability, this study made a new trial regarding social vulnerability assessment to air pollution. With the projection pursuit cluster (PPC) model, the top three factors contributing to social vulnerability index (SVI) were discovered and SVI and SVI dimensions (susceptibility, exposure, and adaptability) were evaluated. Results revealed that adaptability values are higher than susceptibility and exposure values. SVI is in a poor condition as, for the whole region, most values belong to the high-medium level. High SVI values mainly appear in the northern and the southern ends of study area. SVI in Shanghai is lower than in Jiangsu and Zhejiang provinces. On the scale of prefecture-level city, it can be found that the low-value centers of SVI always occurred in urban core areas. The spatial variation and inequality in social vulnerability provide policy-makers a scientific basis for air pollution prevention and sustainable management.