Health‐related quality of life (HRQoL) is one of the most important indicators in assessing the health and well‐being of HIV‐positive patients. The present study investigated the HRQoL of HIV patients referred to Abadan’s Voluntary Counseling and Testing (VCT) center in 2019. In this cross‐sectional study, a total of 134 HIV⁺ patients referred to Abadan’s VCT center were selected through convenience sampling. Demographic information was collected through a researcher‐made checklist; the patients’ status and health information were collected through electronic medical records of HIV⁺ patients and their records at the VCT center. The HRQoL index was assessed using the World Health Organization (WHOQOL‐BREF) questionnaire. Data analysis was carried out using simple and multiple linear regression as well as a t‐test in SPSS software. A P value < 0.05 was considered as the significance level in all tests. The mean of the HRQoL in all the participating patients was 56.42 ± 22.66. The highest and lowest mean scores of HRQoL domains were related to social relationships (57.53 ± 24.73) and environmental health (53.68 ± 19.07). There was a positive significant relationship between the marital status, residency, years of education, duration of infection, transmission route, and antiretroviral (ARV) therapy with the score of the HRQoL. The results showed a moderate score for the mean HRQoL and its domains. The present study revealed the necessity of improving HIV⁺ patients’ living conditions, employment status, health education, and mental health care.

Drug-drug interactions (DDIs) between antiretroviral therapy (ART) and commonly used co-medications in HIV patients, especially women, impact treatment efficacy and patient safety. This study aimed to study the prevalence and types of drug-drug interactions (DDIs) between antiretroviral therapy drugs (ARTs) and comedications among a female population with HIV. Additionally, the study investigates the association of these DDIs with ART medication changes and treatment adherence. This cross-sectional study included 632 adult women living with HIV (WLHIV). Data was retrospectively extracted from patient files. Drug.com interaction checker website was used to assess DDIs between ART and non-ART medications. Changes to the ART regimen previously attributed to ART side effects or patient non-adherence were considered drug changes. A total of 429 WLHIV (mean age: 44.05 ± 9.50) were eligible. The prevalence of DDIs between ART and non-ART medications was 21.4%, with 4.7% minor, 18.4% moderate, and 8.9% major interactions. The highest prevalence of DDI was among cardiovascular medication users (71.7%), followed by central nervous system drugs (69.2%). Changing medications resulted in a decrease in DDIs, with significant reductions in total and minor interactions. Participants without DDIs had better adherence to ART. DDI between ART and non-ART medications was significantly associated with ART drug change, even after accounting for side effects attributed to ARTs, indicating an independent twofold association (OR = 1.99, CI 1.04–3.77). Moreover, further adjustments for HIV viral load and CD4 + cell count did not change the significance of the association (OR = 2.01, CI 1.03–3.92). DDIs in WLHIV impact adherence to ART. Altering ART may not be directly related to ART side effects, but rather primarily due to interactions with non-ART medications. Modifying non-ART drug regimens can reduce the likelihood of DDIs.

Depression and anxiety are common comorbidities complicating the care of breast cancer patients, but many patients do not receive the needed care. We aimed to assess utilization of mental health care and its barriers in breast cancer survivors. This cross-sectional study was conducted on 311 patients with breast cancer, in Iran, November 2021 to March 2022. Perceived need and utilization of mental health care and barriers to service utilization were measured based on self-report. Depression, Anxiety, and Stress Scale-21 and Multidimensional Scale of Perceived Social Support were used to assess depression, anxiety, and stress as well as social support, respectively. A linear and logistic regression model was used to analyze the data using SPSS version 22. A P-value less than 0.05 was considered statistically significant. 70.1% of the participants perceived need for mental health care, 28.0% of them had used mental health services, and 72% were classified as having unmet needs. The most common perceived barrier to service use was patients' self-adequacy. The prevalence of extremely severe levels of depression, anxiety, and stress was 14.8%, 23.5%, and 10.6%. Also, 48.6%, 78.5%, and 75.6% of patients received a high level of social support from friends, family, and significant others. Findings highlight a substantial unmet need for mental health care and low utilization of mental health services among breast cancer survivors. Given the significant prevalence of depression, anxiety, and stress in this population, it is imperative to address the underutilization of mental health services and to further examine the barriers preventing patients from seeking the care they require.

Background: Mental disorders are increasingly prevalent among adolescents without appropriate response. There are a variety of reasons for unmet mental health needs, including attitudinal and structural barriers. Accordingly, we investigated perceived mental health needs, using mental health services, and their barriers in adolescents.Method: This cross-sectional study was conducted in 2022 in Shiraz, Iran. Demographic characteristics, the Adolescent Unmet Needs Checklist, and the Young Schema Questionnaire were administered to 348 adolescents aged 13–19 years. Adolescents were classified as having no needs, fully met needs, partially met needs, or wholly unmet needs. Logistic regression analysis was used to determine factors associated with perceived unmet need and refer participants to healthcare centers.Results: 193 (55.5%) adolescents reported perceived need for mental healthcare out of whom, 21.6% reported fully and 21.6% partially unmet needs. Noticeably, only 12.4% of needy participants reported met need. “Reluctance to seek mental healthcare” and “asked but not receiving help” were common barriers to using the services.Conclusion: The present study reveals unmet mental healthcare needs as a significant public health concern among the adolescents. To address this significant concern, reorientation of primary care, removing economic barriers from mental healthcare services, and improving health literacy in the community are recommended.

This study aimed to assess the association between serum zinc level with some inflammatory and immunity factors and the duration of hospitalization and mortality rate in patients diagnosed with Covid-19. In this cross-sectional study, blood samples were taken from polymerase chain reaction (PCR) positive patients. New patients diagnosed with Covid-19, admitted to different public hospital wards, were considered eligible for entering the study. The study was done on 179 hospitalized patients diagnosed with Covid-19. Fourteen patients died during the hospitalization and the in-hospital mortality rate was 7.8%, with 9.1% (13 patients) of patients with serum zinc level less than 70 mcg/dL and 3.4% (1 patient) of patients with zinc levels more than 70 mcg/dL. Higher levels of zinc were significantly associated with a higher and lower level of interferon-gamma (IFN-γ) (p-value = 0.035) and interleukin (IL)-6 (p-value = 0.004), respectively. The level of serum zinc did not have a significant association with mortality even after adjusting for confounding factors. The relationship between zinc level and the duration of hospitalization was also not significant. In conclusion, serum zinc level had an association with IL-6 and IFN-γ level, but it did not have any significant association with hospital duration or mortality.

Background: Adolescence is one of the most important and challenging stages in life. psychological, cognitive and emotional changes during this period can expose adolescents to high risk behaviors. Objectives: The current study examined the effectiveness of resilience training on emotional intelligence (EI) and assessed gender differences in this regard among adolescents living in the outskirts of Shiraz, Iran. Methods: This pre-post study included 191 students and used an intervention consisting of nine resilience-training sessions. The evaluated outcomes were EI and its 15 components. The paired-samples and independent-samples t-tests were used to analyze the data. Results: Out of 191 students, 88 (46.1%) were boys. Before and after the intervention, the mean EI score for boys was 312.52 ± 37.79 and 327.31 ± 37.75, while for girls, it was 310.74 ± 30.05 and 312.20 ± 29.51, respectively. Following the intervention, the scores of boys in problem-solving (P = 0.007), happiness (P = 0.001), emotional self-awareness (P = 0.044), optimism (P = 0.029), self-regard (P = 0.046), impulse control (P = 0.013), and social responsibility (P = 0.042), as well as the total score of EI (P = 0.005), increased significantly. However, only the optimism score (P = 0.004) rose significantly in girls post-intervention. In addition, there were significant differences in the mean of problem-solving (P = 0.006), happiness (P = 0.001), impulse control (P = 0.042), and the total score (P = 0.035) between boys and girls, before and after the intervention. Conclusions: Resilience training may help moderate high-risk behaviors among adolescents living on the outskirts of Iran’s major cities, particularly boys. Based on the gender differences in EI components, it was suggested that female adolescents required significantly more attention. Nonetheless, gender differences in EI components were contentious, and it was concluded that a variety of factors, including the socio-cultural context, may be involved.