Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn’s disease (CD) or ulcerative colitis (UC). IBD is characterized by exacerbated innate and adaptive immunity in the gut in association with microbiota dysbiosis and the disruption of the intestinal barrier, resulting in increased bacterial exposure. In response to signals from microorganisms and damaged tissue, innate immune cells produce inflammatory cytokines and factors that stimulate T and B cells of the adaptive immune system, and a prominent characteristic of IBD patients is the accumulation of inflammatory T-cells and their proinflammatory-associated cytokines in intestinal tissue. Upon antigen recognition and activation, CD4 T-cells differentiate towards a range of distinct phenotypes: T helper(h)1, Th2, Th9, Th17, Th22, T follicular helper (Tfh), and several types of T-regulatory cells (Treg). T-cells are generated according to and adapt to microenvironmental conditions and participate in a complex network of interactions among other immune cells that modulate the further progression of IBD. This review examines the role of the CD4 T-cells most relevant to IBD, highlighting how these cells adapt to the environment and interact with other cell populations to promote or inhibit the development of IBD.

BACKGROUND: Aging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide. Previous studies on premature aging syndromes have linked atherosclerosis to defects in A-type lamins, key nuclear envelope components. However, whether these defects influence atherosclerosis during normal aging remains unexplored. Here, we examined how aging affects lamin A/C expression in circulating leukocytes and investigated the impact of manipulating their expression in hematopoietic cells on their function and atherosclerosis progression. METHODS: Flow cytometry assessed lamin A/C expression in human circulating leukocytes. Bone marrow from donor mice was transplanted into lethally irradiated, Ldlr ^−/− -deficient mice to study leukocyte extravasation into the vessel wall via intravital microscopy in the cremaster muscle, and high-fat-diet–induced atherosclerosis via Oil Red O staining of the aorta and carotid arteries. Single-cell RNA sequencing of the aorta was conducted to identify transcriptional changes associated with hematopoietic cell lamin A/C gain-of-function or loss-of-function. RESULTS: Human aging is associated with lower levels of lamin A/C expression in blood-borne leukocytes. To evaluate the functional relationship between hematopoietic lamin A/C expression and atherosclerosis development, we used Lmna -null mice and Lmna ^tg mice, the latter being the first in vivo model of lamin A gain-of-function. Transplanting lamin A/C–deficient bone marrow into Ldlr ^−/− mice increased leukocyte extravasation into the vessel wall and accelerated atherosclerosis. Conversely, transplantation of bone marrow overexpressing lamin A into Ldlr ^−/− receptor mice reduced leukocyte extravasation and atherosclerosis. Single-cell RNA sequencing of atherosclerotic mouse aorta revealed that alterations to hematopoietic cell lamin A/C expression primarily modify the transcriptome of immune cell populations and endothelial cells, affecting their functionality. CONCLUSIONS: We suggest that the age-related decline in lamin A/C expression in blood-borne immune cells contributes to increased leukocyte extravasation and atherosclerosis, highlighting lamin A/C as a novel regulator of age-related atherosclerosis.

The article explores the evolution of research on giftedness and high ability through a bibliometric analysis. It highlights challenges in identifying gifted individuals, who represent approximately 6.5% of students, although biased instruments and discriminatory selection practices may affect the identification of high skilled students. The tripartite model, defining giftedness as a combination of high intellectual ability, exceptional achievement, and potential for excellence, serves as a fundamental framework for this study. Using Dirichlet's latent assignment model, major research topics were identified, and trends from 2013 to 2023 were analyzed based on 1071 publications in the Web of Science database. The analysis revealed that publications focus on topics such as giftedness, talent management, and educational programs, showing a significant increase in research on these areas over the past decade. Key topics included psychometrics, gifted programs, and environmental factors. The United States, Germany, and Spain led in productivity with prominent publications addressing cognitive and socio‐emotional aspects of giftedness. Findings underscore the need for targeted educational interventions, including acceleration and enrichment programs, to address the academic and emotional challenges faced by gifted students. Research is shifting toward understanding the environmental influences on these students, highlighting the importance of supportive educational environment for their success.

Background/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. Methods: To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted. A total of 53,670 documents were retrieved related to opioid scientific production, among which 1423 articles (3%) focused specifically on fentanyl. The 21,546 MeSH terms identified in these documents were analysed by publication year and specific fields: Psychiatry and Psychology, Chemicals and Drugs, Healthcare, Diseases, and Phenomena and Processes. R-statistical/FactoMineR libraries were used for the correspondence analysis. Results: In the first overdose death wave, research focused on improving therapies and reducing side effects. The second wave emphasised detoxification methods with naltrexone, methadone, and behavioural therapies. The third wave addressed psychological treatments and HIV-syringe-sharing prevention. The fourth wave prioritised less addictive analogues and understanding consumer profiles to combat the epidemic. Conclusions: Fentanyl research has evolved alongside real-world challenges, reinforcing the connection between patients’ needs, healthcare professionals’ roles, illicit users, policymakers, and the research community’s contributions to addressing both therapeutic use and its broader societal impact. These findings highlight the necessity for an interdisciplinary approach to scientific research integrating prevention, treatment, education, legal reform, and social support, emphasising the need for public health policies and collaborative research to mitigate its impact.

Oncology has exhibited gender inequalities in leadership and authorship, alongside significant differences in cancer incidence, mortality, and survival rates between sexes. These disparities highlight the urgent need for sex- and gender-specific scientific reporting to improve research accuracy and clinical applications and encourage the same opportunities in research careers. The integration of gender perspective in cancer was assessed by analyzing scientific publications comparing 2011 and 2021. The correlation between the gender of the authors and the different types of cancer studied was examined, as well as the inclusion of the sex and gender variables in the content of the research. The study was STROBE compliant. 3,194 papers were published in 2011 and 6,781 in 2021, signed by at least one Spanish institution. The ratio of female authors per article was 0.39 in 2011 compared to 0.43 in 2021, reaching parity. Gender bias in the content of scientific articles, as measured by a 10-item checklist, showed an unfavorable score for perspective integration in both years (1.7/10 and 1.8/10, respectively). In terms of the Gender Balance Index in the analyzed samples of the papers (cells, animals or volunteers/patients), there was an increase from 29 % in 2011 to 43 % in 2021. Breast cancer research was dominated by female authors, whereas lung cancer research was predominantly by parity or male authorship, and no differences in author groups in colorectal cancer research were observed. Greater efforts and commitments are needed from government institutions, funding agencies, and academic structures to promote sex/gender integration in cancer research.