Dr Nahed Ismail is a Clinician-Scientist and Professor of Pathology at University of Illinois in Chicago. She received her medical degree from Tanta University, Egypt; a MS degree from the University of Toronto, Canada; and a PhD degree from the Department of Microbiology and Immunology at the University of Saskatchewan, Canada. The goal of Dr Ismail’s research is to mechanistically define the cellular and molecular host-pathogen interactions that are involved in the pathobiology of acute liver injury and sepsis caused by Ehrlichia species. Ehrlichia infect macrophages and hepatocytes where they reside in a unique endosomal compartment. They cause human monocytic ehrlichiosis, an acute potentially fatal disease that is quite challenging to diagnose and treat, and for which no vaccine is available or in the pipeline. For the past decade, her research has focused on the innate and adaptive immune mechanisms by which Ehrlichia causes dysregulated inflammation and liver injury. We have determined that Ehrlichia hijack several host cell signaling pathways to evade innate host responses, and performed several in vivo and in vitro studies to understand the role of these pathways in the pathogenesis of Ehrlichia-induced liver injury and sepsis. Dr Ismail has an h-Index of 38 and her papers have been cited more than 16,100 times Google Scholar, 17 October 2023).