Chunchao Han

Dr. Chunchao Han

orcid

Research Focus & Metrics

Academic Career Length

16Years (2011-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2015 in Evidence-Based Complementary and Alternative Medicine
Verified
Journal Article
Open access
PDF file
HZHui Zhang
Hui Zhang
YTYibo Tang
Yibo Tang
YZYing Zhang
Ying Zhang
SZShuofeng Zhang
Shuofeng Zhang
JQJing Qu
Jing Qu
ZLZhenquan Liu
Zhenquan Liu
Fucoxanthin, an allenic carotenoid, can be isolated from edible brown seaweeds. Recent studies have reported that fucoxanthin has many physiological functions and biological properties, such as antiobesity, antitumor, antidiabetes, antioxidant, anti-inflammatory, and hepatoprotective activities, as well as cardiovascular and cerebrovascular protective effects. Therefore, fucoxanthin can be used as both medicinal and nutritional ingredient to prevent and treat chronic diseases. Although fucoxanthin possesses many medicinal ingredient and nutritional qualities, studies indicated that its structure was unstable. In this paper, we consulted the current documents and reviewed structural properties and factors affecting the stability of fucoxanthin. We also reported the metabolism, safety, pharmacological activities, and the methods of improving the bioavailability of fucoxanthin. Based on these studies providing essential background knowledge, fucoxanthin can be developed into marine drugs and nutritional products.

1 January 2015 in Evidence-Based Complementary and Alternative Medicine
Verified
Journal Article
Open access
PDF file
YLYi Liu
Yi Liu
JWJihui Wang
Jihui Wang
WWWei Wang
Wei Wang
HZHanyue Zhang
Hanyue Zhang
XZXuelan Zhang
Xuelan Zhang
CHChunchao Han
Chunchao Han
Cordyceps sinensis, also called DongChongXiaCao (winter worm, summer grass) in Chinese, is becoming increasingly popular and important in the public and scientific communities. This study summarizes the chemical constituents and their corresponding pharmacological actions ofCordyceps sinensis. Many bioactive components ofCordyceps sinensishave been extracted including nucleoside, polysaccharide, sterol, protein, amino acid, and polypeptide. In addition, these constituents’ corresponding pharmacological actions were also shown in the study such as anti-inflammatory, antioxidant, antitumour, antiapoptosis, and immunomodulatory actions. Therefore can use different effects ofC. sinensisagainst different diseases and provide reference for the study ofCordyceps sinensisin the future.

8 May 2018 in BioMed Research International
Verified
Journal Article
Open access
PDF file
MZMengmeng Zheng
Mengmeng Zheng
YXYizhou Xin
Yizhou Xin
YLYujuan Li
Yujuan Li
FXFangxue Xu
Fangxue Xu
XXXiaozhi Xi
Xiaozhi Xi
CHChunchao Han
Chunchao Han
Ginseng is a traditional Chinese medicine with a wide range of pharmacological activities. Ginsenosides are the major constituents of ginseng. Ginsenosides have the unique biological activity and medicinal value, such as antitumor, anti-inflammatory, antioxidation, and inhibition of cell apoptosis. With the increase of stress in life, the incidence of nervous system diseases is also increasing. Neurological diseases pose a huge burden on people’s life and health. In recent years, some studies have shown that ginsenosides have a certain role in the prevention and treatment of neurological diseases. However, the research is still in its infancy, and the relevant mechanisms are complex. In the paper, we review the effects and mechanisms of ginsenosides on epilepsy, depression, cerebral ischemia reperfusion injury, Alzheimer’s disease, and Parkinson’s disease. We hope to provide a theoretical basis for the treatment of nervous system diseases by ginsenosides.

14 December 2017 in BioMed Research International
Verified
Journal Article
Open access
PDF file
MZMeng-Meng Zheng
Meng-Meng Zheng
FXFang-Xue Xu
Fang-Xue Xu
YLYu-Juan Li
Yu-Juan Li
XXXiao-Zhi Xi
Xiao-Zhi Xi
XCXiao-Wei Cui
Xiao-Wei Cui
XZXuelan Zhang
Xuelan Zhang
Ginseng is a traditional Chinese medicine and has the extensive pharmacological activity. Ginsenosides are the major constituent in ginseng and have the unique biological activity and medicinal value. Ginsenosides have the good effects on antitumor, anti-inflammatory, antioxidative and inhibition of the cell apoptosis. Studies have showed that the major ginsenosides could be converted into rare ginsenosides, which played a significant role in exerting pharmacological activity. However, the contents of some rare ginsenosides are very little. So it is very important to find the effective way to translate the main ginsenosides to rare ginsenosides. In order to provide the theoretical foundation for the transformation of ginsenoside in vitro, in this paper, many methods of the transformation of ginsenoside were summarized, mainly including physical methods, chemical methods, and biotransformation methods.

1 October 2019 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
HCHui Cao
Hui Cao
SMShan Ma
Shan Ma
HGHong Guo
Hong Guo
XCXiaowei Cui
Xiaowei Cui
SWShanshan Wang
Shanshan Wang
CHChunchao Han
Chunchao Han

1 May 2018 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
YLYujuan Li
Yujuan Li
FXFangxue Xu
Fangxue Xu
MZMengmeng Zheng
Mengmeng Zheng
XXXiaozhi Xi
Xiaozhi Xi
XCXiaowei Cui
Xiaowei Cui
CHChunchao Han
Chunchao Han