Background/Objectives: Dietary recommendations are an essential part of guidelines for the best management of chronic cardiovascular diseases. The present study aimed to validate the Greek version of Cardiovascular Diet Questionnaire 2 (CDQ-2) and to assess the dietary habits among cardiovascular patients. Methods: A single-center cross-sectional observational study was conducted. The study population was cardiovascular patients that were users of a private primary healthcare clinic. The data were collected between December 2024 and January 2025. The questionnaire was translated from French, back-translated, and reviewed by a committee of experts. The MEDAS was used as a gold standard. The psychometric measurements that were performed included reliability coefficients and Explanatory Factor Analysis (EFA). Results: The total sample comprised 90 individuals. The Cronbach’s α was 0.97. A bivariate Pearson’s correlation established that there was a strong, statistically significant linear relationship between the CDQ-2 and MEDAS scores, with r(90) = 0.962 and p < 0.001. Cardiovascular patients seemed to have suboptimal dietary patterns, as indicated by the relatively low mean CDQ-2 score of 2.9 (SD = 17.2), along with a mean MEDAS score of 8 (SD = 5.2), where younger individuals (p < 0.001), males (p = 0.042), single/divorced/widowed individuals (p < 0.001), individuals with lower physical activity (p = 0.001), and active smokers (p = 0.022) demonstrated significantly poorer adherence to the optimal cardiovascular dietary status. Conclusions: The survey indicated that CDQ-2 was a valid and reliable scale to use in cardiovascular patients in Greece. Also, the patients were characterized by suboptimal dietary habits, indicating the need for personalized interventions to improve their dietary habits.

Glioma, specifically gliobastoma, represents the commonest central nervous system malignancy and is notoriously challenging to treat, with only a minimal number of patients surviving beyond a year after diagnosis. The available treatment options include surgical resection, radiotherapy, and chemotherapy, mainly with temozolomide. However, gliomas can be particularly treatment resistant and novel options are currently being researched. One such agent is ONC201, the first member of the imipridone class and a TNF-related apoptosis inducing ligand (TRAIL)-inducing compound, which has shown positive results in the first preliminary clinical reports about its application in glioma patients, while also being safe and well-tolerated. Particular promise has been shown for the H3K27M mutated glioblastomas, with more trials focusing on this patient subset. It is likely that this compound will be added in the treatment algorithms of glioma in the future, although more research is still needed.

Takotsubo syndrome (TTS) was first described in postmenopausal women with transient regional wall motion abnormalities. The trigger is usually an emotional or physical stress. The catecholamine hypothesis seems to be the most prevailing. The main difference between TTS and acute coronary syndromes is that there is no obstructive coronary disease to explain the regional abnormalities. In this form, the left ventricle resembles the fishing jar which is used to trap octopus in Japan. However, to date more atypical forms are recognized. Also, the syndrome is not limited to older women. Nowadays, TTS is presented even in pregnancy and postpartum females. Our experience revealed cases of patients during these periods and some of them suffered from reverse Takotsubo. Additionally, the initial diagnosis in some patients was other than TTS. Due to these findings, we suggest that this type of TTS is not very rare but underestimated. For this reason, further studies are needed to support and explain this condition.

Background/Objectives: Dietary recommendations are an essential part of guide-lines for the best management of cardiovascular chronic diseases. The present study aimed to validate the Greek version of Cardiovascular Diet Questionnaire 2 (CDQ-2) and to assess dietary habits among cardiovascular patients. Methods: A cross-sectional observational study was conducted. The study population was cardio-vascular patients, users of a private Primary Health Care clinic. The data was collected between December 2024 and January 2025. The questionnaire was translated from French, back-translated, and reviewed by a committee of experts. The MEDAS was used as a gold standard. The psychometric measurements that were performed in-cluded reliability coefficients and Explanatory Factor Analysis (EFA). Results: The to-tal sample comprised 90 individuals. The Cronbach’s α was 0.97. A bivariate Pearson's correlation established that there was a strong, statistically significant linear relation-ship between CDQ-2 and MEDAS scores, r(90) = 0.962, p < 0.001. Cardiovascular pa-tients seem to have suboptimal dietary patterns as indicated by the relatively low mean CDQ-2 score of 2.9 (SD = 17.2), along with a mean MEDAS score of 8 (SD = 5.2), with younger (p< 0.001), males (p=0.042), single/divorced/widowed (p< 0.001), individ-uals with lower physical activity (p=0.001), and active smokers (p=0.022) demonstrat-ing significantly poorer adherence to the optimal cardiovascular dietary status. Con-clusions: The survey indicates that the CDQ-2 is a valid and reliable scale to use in cardiovascular patients in Greece. Also, patients are characterized by suboptimal die-tary habits, indicating the need for personalized interventions to improve their dietary habits.