HIV viral reservoirs are established very early during infection. Resident memory T cells (T_RM) are present in tissues such as the lower female genital tract, but the contribution of this subset of cells to the pathogenesis and persistence of HIV remains unclear. Here, we show that cervical CD4⁺T_RM display a unique repertoire of clusters of differentiation, with enrichment of several molecules associated with HIV infection susceptibility, longevity and self-renewing capacities. These protein profiles are enriched in a fraction of CD4⁺T_RM expressing CD32. Cervical explant models show that CD4⁺T_RM preferentially support HIV infection and harbor more viral DNA and protein than non-T_RM. Importantly, cervical tissue from ART-suppressed HIV⁺ women contain high levels of viral DNA and RNA, being the T_RM fraction the principal contributor. These results recognize the lower female genital tract as an HIV sanctuary and identify CD4⁺T_RM as primary targets of HIV infection and viral persistence. Thus, strategies towards an HIV cure will need to consider T_RM phenotypes, which are widely distributed in tissues.

We conducted a systematic review of the literature on the use of mobile phones for weight loss. A total of 43 studies were identified on obese or overweight adults, aged 18 years or over. After review, ten articles met the inclusion criteria. There were 19–534 participants per study. Participants were from European, Asian and North American regions. The mean body mass index (BMI) of the subjects varied from 22 to 36 kg/m². Two studies used text messaging or multimedia messaging. All the other studies used mobile-phone apps or web-based programmes that could be accessed from mobile phones as a part of a weight-loss intervention or for evaluating their potential for use and their acceptance. Most studies lasted 2–4 months and the maximum duration was 1 year. All but two studies showed reductions in the participants’ bodyweight, BMI, waist circumference and body fat in the various interventions. There appeared to be a proportional relationship between weight loss and programme use. The programmes most benefited those who took a pro-active approach to everyday problems. Frequent self-recording of weight seemed to be important, as was the personalisation of the intervention (counselling and individualized feedback). Finally, a social support system acted as a motivational tool.

Patients undergoing major surgery are predisposed to a decrease in functional capacity as a response to surgical stress that can delay post-operative recovery. A prehabilitation program consists of patient preparation strategies before surgery, and include pre-operative measures to improve functional capacity and enhance post-operative recovery. Multimodal prehabilitation may include exercise, nutritional counseling, psychological support, and optimization of underlying medical conditions, as well as cessation of unfavorable health behaviors such as smoking and drinking. Currently, there are no standardized guidelines for prehabilitation, and the existent studies are heterogeneous; however, multimodal approaches are likely to have a greater impact on functional outcomes than single management programs. We have reviewed the literature on prehabilitation in general, and in gynecologic surgery in particular, to identify tools to establish an optimal prehabilitation program within an Enhanced Recovery After Surgery (ERAS) protocol for gynecologic oncology patients. We suggest a safe, reproducible, functional, and easy-to-apply multimodal prehabilitation program for gynecologic oncology practice based on patient-tailored pre-operative medical optimization, physical training, nutritional counseling, and psychological support. The analysis of the prehabilitation program implementation in an ERAS protocol should undergo further research in order to test the efficacy on surgical outcome and recovery after surgery.

The aim of this paper is to reflect on the importance of taking a broader and more comprehensive (and, above all, social and cultural) approach when problematizing dietary patterns in terms of sustainability. In this regard, the building of cultural capital around a medicalized concept such as the Mediterranean diet, in addition to being used to legitimize the actions carried out from the field of health, allows the highlighting of the value of social capital around this denomination. This article also analyzes how certain actions aimed at valuing the building of cultural capital related to the Mediterranean diet, such as the inscription as intangible cultural heritage of humanity by UNESCO, or the value recognition of the social capital constructed around them, have been frequently neglected and considered as subordinate to other perspectives considered more central and focused on both health and the environment.