Histology has not been accepted as a valid predictor of the biological behavior of extra-meningeal solitary fibrous tumors (SFTs). Based on the lack of a histologic grading system, a risk stratification model is accepted by the WHO to predict the risk of metastasis; however, the model shows some limitations to predict the aggressive behavior of a low-risk/benign-appearing tumor. We conducted a retrospective study based on medical records of 51 primary extra-meningeal SFT patients treated surgically with a median follow-up of 60 months. Tumor size (p = 0.001), mitotic activity (p = 0.003), and cellular variants (p = 0.001) were statistically associated with the development of distant metastases. In cox regression analysis for metastasis outcome, a one-centimeter increment in tumor size enhanced the expected metastasis hazard by 21% during the follow-up time (HR = 1.21, CI 95% (1.08–1.35)), and each increase in the number of mitotic figures escalated the expected hazard of metastasis by 20% (HR = 1.2, CI 95% (1.06–1.34)). Recurrent SFTs presented with higher mitotic activity and increased the likelihood of distant metastasis (p = 0.003, HR = 12.68, CI 95% (2.31–69.5)). All SFTs with focal dedifferentiation developed metastases during follow-up. Our findings also revealed that assembling risk models based on a diagnostic biopsy underestimated the probability of developing metastasis in extra-meningeal SFTs.

Background: Students, due to their specific academic and psychosocial conditions, are at higher risk of suicide compared with the general population, and suicide is one of the leading causes of death among students worldwide. Aims: To investigate the prevalence of suicidal ideation and suicide attempts among Iranian university students. Method: A systematic search was conducted in international and national databases, including Scopus, Web of Science, PsycINFO, PubMed and Magiran, up to February 2025. Title and abstract screening was performed by a single reviewer. Two reviewers independently undertook full-text screening (study selection) and data extraction. Data were analysed using Stata 16. The heterogeneity of studies was tested with Cochran’s Q and quantified with the I ² statistic. To explore the sources of heterogeneity, we performed sensitivity analyses and meta-regression. The protocol was registered in the International Registration of Systematic Reviews (no. CRD42023471340). Results: We included 28 studies in this research. The pooled prevalence of suicidal ideation, 12-month suicide attempts and lifetime suicide attempts among Iranian students was 17% (95% CI: 13–21%), 3% (95% CI: 2–4%) and 8% (95% CI: 6–10%), respectively, with substantial heterogeneity ( I ² = 94.85, 91.16 and 93.46%, respectively). Conclusions: This study highlights the high prevalence of suicidal ideation and suicide attempts among Iranian university students, underscoring the need for effective preventive strategies and further research.

Background: COVID-19 can lead to hematological abnormalities, including anemia. Pre-existing anemia can exacerbate the severity of the disease by increasing the peripheral tissue demand for oxygen. Both conditions can contribute to hypoxia. Objective: We aimed to investigate the relationship between COVID-19 infection and on-admission anemia in critically ill children and assess their effects on severe outcomes. Methods: This retrospective study was conducted at Children’s Medical Center during the COVID-19 pandemic. Patients were divided into two groups based on the first hemoglobin level: Anemic and non-anemic. For statistical analysis, we used univariate and multivariate logistic regression models in SPSS and Stata software. Results: A total of 133 patients were enrolled with a mean age of 63.2 months. Fifty-eight patients had anemia for age, and 75 were non-anemic. Among the patients, 53.5% of females and 35.6% of males were anemic (P = 0.04). Additionally, 50.5% of anemic patients had significant prehospital comorbidities compared with 20% of previously healthy patients (P = 0.03). Overall, 72.9% of patients survived, and 27.1% died. Using univariate analysis, death occurred significantly more in anemic patients compared to others (OR: 2.27, 95% CI: 1.042 - 4.948, P = 0.037). A logistic regression model was used to adjust the impact of potential confounders, showing that death occurred 1.82 times more often in anemic patients versus non-anemic patients (OR: 1.77, 95% CI: 0.79 - 3.98, P = 0.162). Furthermore, 54.9% of patients needed vasoactive agents, and 42.7% underwent mechanical ventilation (MV) (P = 0.413 and 0.155, respectively). Conclusions: The mortality rate in our study was 27.1%. In the logistic regression model adjusting for comorbidity and sex, we found a small effect relationship between anemia and mortality. However, wide confidence intervals and non-significant p-values indicate the low power of the study, mostly due to the small sample size. Further prospective studies with a larger sample size are recommended to determine the exact relationship between anemia and mortality.

Background: Individuals with schizophrenia have shown distinct cancer incidence patterns. Aims: We aimed to assess whether their cancer-related mortality differs from the general population overall, by gender and by specific cancer types. Method: We systematically searched Scopus, Web of Science, PsycINFO, PubMed and Embase, up to December 2025. Each record was independently screened by two reviewers, and data were independently extracted by two investigators. Two authors assessed the quality of the included articles with the Newcastle–Ottawa Scale. Analyses were conducted using Stata version 16; between-study heterogeneity was evaluated with Cochran’s Q -statistic and the I ² -statistic, and potential sources of heterogeneity were further examined through exploratory meta-regression. Results: Meta-analysis of cohort studies showed that individuals with schizophrenia had a 55% higher risk of cancer-related death than the general population (standardised mortality ratio (SMR) 1.55; 95% CI 1.16–2.07). In gender-stratified analyses, SMRs for all cancers combined were 1.37 (95% CI 1.01–1.87) in men and 1.43 (95% CI 1.15–1.79) in women. Site-specific SMRs were 1.77 (95% CI 1.17–2.68) for breast, 2.40 (95% CI 2.35–2.45) for respiratory, 1.54 (95% CI 1.35–1.76) for gastrointestinal, 2.32 (95% CI 0.72–7.45) for haematologic, 4.43 (95% CI 0.71–27.62) for skin and soft tissue, 3.03 (95% CI 1.96–4.69) for urogenital and 1.01 (95% CI: 0.36–2.83) for other cancers, although precision varied considerably across cancer sites. Conclusions: Schizophrenia was associated with substantially elevated cancer-related mortality compared with the general population. These findings underscore the need for earlier cancer detection and guideline-concordant, integrated physical and mental healthcare for this high-risk group.

Background: To deal with health problems, using an approach, based on prevention perspective, consist of different types of prevention, can be a proper way to manage the health problems such as surgical site infections (SSIs). Objective: Introducing an action plan from the perspective of “prevention” for dealing with surgical site infections (SSIs). Evidence Acquisition: We have used 5 known prevention levels as a simple approach for dealing with surgical site infections. For gathering information, electronic databases, including Scopus, Medline, ISI, IranMedex, and Irandoc sites were used. Results: For prevention of surgical site infection, a comprehensive evidence based instruction, consist of 75 related factors and 74 proposed measurable and operational preventive activities was developed. Conclusions: We concluded that, to dealing with surgical site infections use of the proposed action plan may be useful. Even we believe that, this approach can be used to dealing with any health problems including diseases, disorders, accidents and events. Keywords: Surgical Site Infection; Prevention; Prevention Levels; Risk Factors; Hospital Infection Control