Bhuvana Plakkot

Ms. Bhuvana Plakkot

Physiological Sciences, Oklahoma State University, Stillwater, Minnesota, USA
orcid
avatar
Co-authors
avatar
Following
avatar
Followers

Research Focus & Metrics

Explore full metrics on Scilit

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
14 September 2022 in Journal of Virology
Verified
Journal Article
Open access
MSMahesh Kumar Sivasubramanian
Mahesh Kumar Sivasubramanian
RMRaisa Monteiro
Raisa Monteiro
KHKelly S. Harrison
Kelly S. Harrison
BPBhuvana Plakkot
Bhuvana Plakkot
MSMadhan Subramanian
Madhan Subramanian
Clinton JonesClinton Jones
Clinton Jones
HSV-1 (herpes simplex virus 1), an important human pathogen, establishes lifelong latency in neurons in trigeminal ganglia and the central nervous system. In contrast to productive infection, the only viral transcript abundantly expressed in latently infected neurons is the latency associated transcript (LAT).
28 February 2023 in Cells
Verified
Journal Article
Open access
PDF file
BPBhuvana Plakkot
Bhuvana Plakkot
AAAshley Di Agostino
Ashley Di Agostino
MSMadhan Subramanian
Madhan Subramanian
The hypothalamus, one of the major regulatory centers in the brain, controls various homeostatic processes, and hypothalamic neural stem cells (htNSCs) have been observed to interfere with hypothalamic mechanisms regulating aging. NSCs play a pivotal role in the repair and regeneration of brain cells during neurodegenerative diseases and rejuvenate the brain tissue microenvironment. The hypothalamus was recently observed to be involved in neuroinflammation mediated by cellular senescence. Cellular senescence, or systemic aging, is characterized by a progressive irreversible state of cell cycle arrest that causes physiological dysregulation in the body and it is evident in many neuroinflammatory conditions, including obesity. Upregulation of neuroinflammation and oxidative stress due to senescence has the potential to alter the functioning of NSCs. Various studies have substantiated the chances of obesity inducing accelerated aging. Therefore, it is essential to explore the potential effects of htNSC dysregulation in obesity and underlying pathways to develop strategies to address obesity-induced comorbidities associated with brain aging. This review will summarize hypothalamic neurogenesis associated with obesity and prospective NSC-based regenerative therapy for the treatment of obesity-induced cardiovascular conditions.
7 January 2019 in Biological Rhythm Research
Verified
Journal Article
Closed access
AMAbhina Mohanan
Abhina Mohanan
BPBhuvana Plakkot
Bhuvana Plakkot
RKRaji Kanakkaparambil
Raji Kanakkaparambil
A study was conducted in cross-bred (CB) Malabari goats of Southern India, Kerala to assess the pattern of change in biochemical constituents of follicular fluid during final stages of follicle development. One hundred and twenty goat ovaries were collected from local slaughter houses. After classifying the antral follicles based on size i.e. small (1–3 mm) and large (3–6 mm), the follicular fluid was aspirated and analysed to estimate the concentration of various biochemical constituents including total protein, albumin, globulin, glucose, triglycerides, cholesterol, high-density lipoprotein (HDL) and steroid hormones. The results showed that the concentration of glucose in follicular fluid was significantly higher (p < 0.05) in small follicles compared the large ones. However, the level of HDL and oestrogen was significantly higher (p < 0.05) in large follicles. Follicular fluid protein, albumin, globulin, triglycerides, cholesterol, and progesterone did not differ significantly between the small and large follicles. The results of the present study suggest that the biochemical constituents in the antral follicular fluid vary with the follicular size and the data would contribute to better understanding of the follicular fluid metabolite dynamics of goat ovarian follicles which imparts oocyte competence for fertilization during later developmental stages.
24 May 2024
Verified
Book Chapter
Closed access
PDF file
AMAbhina Mohanan
Abhina Mohanan
SHS. L. Harilal
S. L. Harilal
BPBhuvana Plakkot
Bhuvana Plakkot
BPBiju Pottakkat
Biju Pottakkat
RKRaji Kanakkaparambil
Raji Kanakkaparambil
9 May 2026 in Pathogens
Verified
Journal Article
Open access
PDF file
MWMelanie Whitmore
Melanie Whitmore
KHKelly S. Harrison
Kelly S. Harrison
HSHafez Sadeghi
Hafez Sadeghi
BPBhuvana Plakkot
Bhuvana Plakkot
UVUdayKiran Venugopal
UdayKiran Venugopal
Clinton JonesClinton Jones
Clinton Jones
Following acute infection, herpes simplex virus type 1 (HSV-1) establishes life-long latency in neurons. Although sensory neurons in trigeminal ganglia (TG) are primary sites for latency, the brainstem is also an important site for latency. The rationale for examining the principal sensory nucleus of the spinal trigeminal tract (Pr5) receives afferent inputs from TG. Notably, the (LC) is indirectly linked to Pr5. Our previous studies revealed that senescent cells and inflammation were detected in the Pr5 and LC of aged mice and young mice that are latently infected with HSV-1. To expand our understanding of how HSV-1 influences senescence and inflammation in Pr5 and LC, NanoString studies in mice latently infected with wild-type HSV-1 or a latency-associated transcript (LAT) null mutant (dLAT2903) was compared to age-matched uninfected C57Bl/6 male and female mice. LAT is the only viral gene abundantly expressed during latency, suggesting it influences cellular gene expression during latency. Cellular genes that regulate neuron differentiation, axonal projection, and pro-inflammatory mediators were more prevalent in mice latently infected with wild-type (wt) HSV-1 and dLAT2903 versus uninfected mice. Finally, these studies revealed that latency in Pr5 and LC is a dynamic process.